分子结

分子结（molecular knot，也称为knotane）为一种类似绳结的机械互锁分子结构^[2]。三叶结组态的分子结为手性分子，至少有二个对映异构，像DNA和一些特定蛋白都是自然生成的分子结。乳铁蛋白和其线性的异构物有不同的性质。其他的合成分子结因为其球状外形及奈米尺寸，因此是奈米科技中潜在的建设方块。第一个合成分子结是由Sauvage在1989年合成^[3]。

一个三叶的分子结，其中有二个终端的铜离子，由让-皮埃尔·索瓦日和其同事发现^[1]

另一个三叶的分子结，由Vögtle及其同事在Angew. Chem. Int. Edit., 2000, 1616-1618.中发表

knotane一词是由Fritz Vögtle等在2000年在应用化学期刊中创建，类似Rotaxane（轮烷）、catenane（索烃）^[4][5]，不过IUPAC尚未核定此一词语。

已发现许多合成分子结的方式^{[6][7][8][9][10][11]}。也已找到合成五叶（英语：pentafoil）分子结的方式^[12]。

相关条目

• 大环 (化学)（英语：Macrocycle）
• 超分子化学

参考资料

1. Albrecht-Gary, A. M.; Meyer, M.; Dietrich-Buchecker, C. O.; Sauvage, J. P.; Guilhem, J.; Pascard, C. Dicopper (I) trefoil knots: Demetallation kinetic studies and molecular structures. Recueil des Travaux Chimiques des Pays-Bas. 2 September 2010, 112 (6): 427–428. doi:10.1002/recl.19931120622.
2. Lukin, Oleg; Vögtle, Fritz. Knotting and Threading of Molecules: Chemistry and Chirality of Molecular Knots and Their Assemblies. Angewandte Chemie International Edition. 25 February 2005, 44 (10): 1456–1477. PMID 15704147. doi:10.1002/anie.200460312.
3. Dietrich-Buchecker, Christiane O.; Sauvage, Jean-Pierre. A Synthetic Molecular Trefoil Knot. Angewandte Chemie International Edition in English. February 1989, 28 (2): 189–192. doi:10.1002/anie.198901891.
4. Lukin O, Vögtle F. Knotting and Threading of Molecules: Chemistry and Chirality of Molecular Knots and Their Assemblies. Angewandte Chemie International Edition. 2005, 44 (10): 1456–1477. PMID 15704147. doi:10.1002/anie.200460312.
5. Safarowsky O, Nieger M, Fröhlich R, Vögtle F. A Molecular Knot with Twelve Amide Groups - One-Step Synthesis, Crystal Structure, Chirality. Angewandte Chemie International Edition. 2000, 39 (9): 1616–1618. PMID 10820452. doi:10.1002/(SICI)1521-3773(20000502)39:9<1616::AID-ANIE1616>3.0.CO;2-Y.
6. Ashton, Peter R.; Matthews, Owen A.; Menzer, Stephan; Raymo, Françisco M.; Spencer, Neil; Stoddart, J. Fraser; Williams, David J. Molecular Meccano, 27. A Template-directed Synthesis of a Molecular Trefoil Knot. Liebigs Annalen. December 1997, 1997 (12): 2485–2494. doi:10.1002/jlac.199719971210.
7. Rapenne, Gwénaël; Dietrich-Buchecker , and Jean-Pierre Sauvage *, Christiane; Sauvage, Jean-Pierre. Copper(I)- or Iron(II)-Templated Synthesis of Molecular Knots Containing Two Tetrahedral or Octahedral Coordination Sites. Journal of the American Chemical Society. February 1999, 121 (5): 1002–1015. doi:10.1021/ja982239+.
8. Feigel, Martin; Ladberg, Rüdiger; Engels, Simon; Herbst-Irmer, Regine; Fröhlich, Roland. A Trefoil Knot Made of Amino Acids and Steroids. Angewandte Chemie International Edition. 25 August 2006, 45 (34): 5698–5702. doi:10.1002/anie.200601111.
9. Guo, Jun; Mayers, Paul C.; Breault, Gloria A.; Hunter, Christopher A. Synthesis of a molecular trefoil knot by folding and closing on an octahedral coordination template. Nature Chemistry. 7 February 2010, 2 (3): 218–222. doi:10.1038/nchem.544.
10. Barran, Perdita E.; Cole, Harriet L.; Goldup, Stephen M.; Leigh, David A.; McGonigal, Paul R.; Symes, Mark D.; Wu, Jhenyi; Zengerle, Michael. Active-Metal Template Synthesis of a Molecular Trefoil Knot. Angewandte Chemie International Edition. 16 December 2011, 50 (51): 12280–12284. doi:10.1002/anie.201105012.
11. Carina, Riccardo F.; Dietrich-Buchecker, Christiane; Sauvage, Jean-Pierre. Molecular Composite Knots. Journal of the American Chemical Society. January 1996, 118 (38): 9110–9116. doi:10.1021/ja961459p.
12. Ayme, Jean-François; Beves, Jonathon E.; Leigh, David A.; McBurney, Roy T.; Rissanen, Kari; Schultz, David. A synthetic molecular pentafoil knot. Nature Chemistry. 6 November 2011, 4 (1): 15–20. PMID 22169866. doi:10.1038/nchem.1193.