preclinical development

药物研发是指一旦通过药物发现确定了先导化合物，就将一种新的药物推向市场的过程。具體步驟包括对微生物和动物的临床前研究（英语：Preclinical development），申请监管機構批准（例如獲得美国食品药品监督管理局批准）後即可為研究性新药（英语：Investigational New

Eli M. Wallace, Lance Williams, Thomas D. Aicher. Discovery and preclinical development of AR453588 as an anti-diabetic glucokinase activator. Bioorganic

Theodora; Duis, Jessica; Servais, Laurent. Therapies in preclinical and clinical development for Angelman syndrome. Expert Opinion on Investigational

Nathan; Binder, Joseph; Chen, Emily; Eng, Heather; Hammond, Holly. Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor

1371/journal.pone.0007965.  Disch, Bryan; et al. Development and Characterization of a Preclinical Model of Breast Cancer Lung Micrometastatic to Macrometastatic