泼尼松在某些人中,它也可能引起抑鬱或是焦慮及抑鬱症狀。 長期副作用包括庫興氏綜合症、類固醇癡呆綜合症(英语:steroid dementia syndrome )、軀幹體重增加、骨質疏鬆症、青光眼、白內障、二型糖尿病,及隨著劑量減少或停止後出現的抑鬱。潑尼松也可導致白細胞增多症(英语:Leukocytosis)。
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生命科学突破奖 receptor)、醛固酮合酶(英语:Aldosterone synthase)和甾体11-β-羟化酶(英语:Steroid 11β-hydroxylase))及生物化學机制。("For the discovery of genes and biochemical mechanisms