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多發性硬化症（multiple sclerosis，MS）或多发性脑脊髓硬化症（multiple cerebrospinal sclerosis），是一種以中枢神经系统白质炎性脱髓鞘病变（英语：Demyelinating disease）为主要特点的自身免疫疾病，因病变具有部位（空间）多发和时间多
Ramirez-Bermudez. Severe impulsiveness as the primary manifestation of multiple sclerosis in a young female. Psychiatry Clin. Neurosci. 2005-12, 59 (6): 739–42