49号州际公路（Interstate 49，简称I-49）是美国州际公路系统的一部分，全部位于路易斯安那州。南起拉法叶（与10号州际公路交汇），北至什里夫波特（与20号州际公路交汇）。全长208.60英里（335.71公里）。
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