补体成分6

补体成分C6（Complement component 6），在人体内是一个由C6基因编码的蛋白质，是补体系统的一部分，功能是形成膜攻击复合物（MAC）。C6缺陷的患者更易被细菌感染^[6][7]:41-45。

补体成分6
已知的结构 PDB 直系同源搜索: PDBe RCSB PDBID列表 3T5O、​4A5W、​4E0S
识别号
别名	C6；, complement C6
外部ID	OMIM：217050 MGI：88233 HomoloGene：47 GeneCards：C6
相关疾病
complement component 9 deficiency[1]
基因位置（人类） 染色体 5号染色体[2] 基因座 5p13.1 起始 41,142,116 bp[2] 终止 41,261,438 bp[2]
基因位置（小鼠） 染色体 小鼠15号染色体[3] 基因座 15 A1|15 1.97 cM 起始 4,756,657 bp[3] 终止 4,844,449 bp[3]
基因本体 分子功能 • 血浆蛋白结合 细胞组分 • 细胞外区域 • 外排体 • 补体系统膜攻击复合物 生物学过程 • positive regulation of activation of membrane attack complex • immune system process • complement activation • in utero embryonic development • 细胞溶解 • regulation of complement activation • 免疫反应 • positive regulation of angiogenesis • 经典途径 • positive regulation of complement activation • 先天免疫系统 Sources:Amigo / QuickGO
直系同源
物种	人类	小鼠
Entrez	729	12274
Ensembl	ENSG00000039537	ENSMUSG00000022181
UniProt	P13671	无数据
mRNA​序列	NM_000065 ​NM_001115131	NM_016704
蛋白序列	NP_000056 ​NP_001108603	无数据
基因位置​（UCSC）	Chr 5: 41.14 – 41.26 Mb	Chr 15: 4.76 – 4.84 Mb
PubMed​查找	[4]	[5]
维基数据
查看/编辑人类 查看/编辑小鼠

7 sources

参考

1. 與補體成分6相關的疾病；在維基數據上查看/編輯參考.
2. GRCh38: Ensembl release 89: ENSG00000039537 - Ensembl, May 2017
3. GRCm38: Ensembl release 89: ENSMUSG00000022181 - Ensembl, May 2017
4. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
6. Entrez Gene: complement component 6.
7. 曹雪涛等. 醫學免疫學 第6版. 北京: 人民卫生出版社. 2013. ISBN 978-7-117-17101-4.

拓展阅读

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外部链接

• 医学主题词表（MeSH）：Complement+C6