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中医专著《黄帝内经·上古天真论篇第一》记载:“中古之时，有至人者，淳德全道，和于阴阳，调于四时，去世离俗，积精全神，游行天地之间，视听八远之外，此盖益其寿命而强者也。亦归于真人。”庄子中也有至人之用心如镜不将不迎的说法。
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