特他洛尔

特他洛尔
临床资料
AHFS/Drugs.com	国际药品名称
给药途径	口服
ATC码	C07AA16 (WHO) ;
法律规范状态
法律规范	处方药（℞-only）;
识别信息
	IUPAC命名法 (±)-1-(tert-Butylamino)-3-(3,4-dihydro-2H-thiochromen-8-yloxy)propan-2-ol; ;
CAS号	83688-84-0
PubChem CID	36920;
IUPHAR/BPS	571;
ChemSpider	33875 ;
UNII	9ZO341YQXP;
KEGG	D07182 ;
ChEMBL	ChEMBL434200 ;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID80865735 ;
ECHA InfoCard	100.073.179
化学信息
化学式	C16H25NO2S
摩尔质量	295.44 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
手性	外消旋体
	SMILES CC(C)(C)NCC(COC1=CC=CC2=C1SCCC2)O;
	InChI InChI=1S/C16H25NO2S/c1-16(2,3)17-10-13(18)11-19-14-8-4-6-12-7-5-9-20-15(12)14/h4,6,8,13,17-18H,5,7,9-11H2,1-3H3 ; Key:HTWFXPCUFWKXOP-UHFFFAOYSA-N ;

特他洛尔（英语：Tertatolol），商品名Artex、Artexal、Prenalex，是一种β受体阻滞剂，用于治疗高血压。它是由法国施维雅制药公司发现的，并在欧洲销售。^[1]

事实速览 临床资料, AHFS/Drugs.com ...

关闭

特他洛尔还被证明可作为血清素5-HT_1A和5-HT_1B受体拮抗剂，类似于普萘洛尔和吲哚洛尔。^[2]^[3]^[4]

4 sources

参见

[1]
Swiss Pharmaceutical Society. Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. 2000. ISBN 3-88763-075-0.
[2]
Langlois M, Brémont B, Rousselle D, Gaudy F. Structural analysis by the comparative molecular field analysis method of the affinity of beta-adrenoreceptor blocking agents for 5-HT1A and 5-HT1B receptors. European Journal of Pharmacology. January 1993, 244 (1): 77–87. PMID 8093601. doi:10.1016/0922-4106(93)90061-d.
[3]
Jolas T, Haj-Dahmane S, Lanfumey L, Fattaccini CM, Kidd EJ, Adrien J, et al. (-)Tertatolol is a potent antagonist at pre- and postsynaptic serotonin 5-HT1A receptors in the rat brain. Naunyn-Schmiedeberg's Archives of Pharmacology. May 1993, 347 (5): 453–463. PMID 7686633. S2CID 22129922. doi:10.1007/bf00166735.
[4]
van Wijngaarden I, Soudijn W, Tulp MT. 5-HT_1A Receptors. Soudijn W, Olivier B, van Wijngaarden I (编). Serotonin Receptors and Their Ligands. Amsterdam: Elsevier. 1997. ISBN 0-444-82041-8.