生平
清嘉庆年间拔贡，授任河南温县知县[1]，后迁光州知州[2]、汝宁府、开封府知府[3]、湖北按察使、河南布政使。道光十五年，官至河东河道总督。道光二十年，赠太子太保，谥号恭勤[3]。栗毓美死后，道光帝和栗毓美生前好友林则徐都为他写了祭文，现两篇祭文碑刻俱都保存良好，该地人称“栗家坟”，为全国重点文物保护单位。
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