吴沈(?—1396年),字浚仲浙江兰溪人,明朝政治人物。

其早年有学问。朱元璋攻下婺州时,召为讲经史。后命为郡学训导[1]。后任翰林院待制,因事降为编修。后再降为翰林院典籍。之后升任东阁大学士[2]。当初制《精诚录》,命沈撰序。一年后为翰林侍书,改国子博士。之后因老辞官还乡[3]

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