磷酸肌醇3-激酶（英語：Phosphoinositide 3-kinase, PI3Ks）又叫磷脂醯環己六醇3-激酶（英語：英語：phosphatidylinositol 3-kinases），是一個參與諸如細胞生長、增殖、分化、移動、存活和胞內運輸等細胞功能的酶家族，從而也參與癌症。

Phosphoinositide Kinases. Annu Rev Biochem. 1998, 67: 481–507. PMID 9759495. doi:10.1146/annurev.biochem.67.1.481.  Cantley LC. The Phosphoinositide 3-Kinase

NOS1AP – nitric oxide synthase 1 (neuronal) adaptor protein PIK3AP1 – phosphoinositide-3-kinase adaptor protein 1 SH2B1 – SH2B adaptor protein 1 SH2B2 – SH2B

Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell. October 1999,

papillomavirus can escape immune recognition through Langerhans cell phosphoinositide 3-kinase activation. Journal of Immunology. 2005-06-01, 174 (11): 7172–7178