陳致虛(1290年~?)為元代著名道教金丹派學者、內丹家。字觀吾,號上陽子。廬陵(今江西吉安)人。著名的內丹理論家,他將金丹派推向全真道,成為全真南宗。
天曆二年(1329年),遇趙友欽(號緣督子)於湖南衡陽,受其所傳金丹之道。其後,又遇青城老人,傳以「先天一氣坎月離日金丹之旨」。著有《金丹大要》十六卷。
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