陸開明在北齊官至通直散騎侍郎。北齊後主時,祖珽奏立文林館,陸開明應召入為文學士。北周建德六年(577年),周武帝率軍攻下鄴城,北齊滅亡。陸開明和陽休之、袁聿修、李祖欽、元修伯、崔達拏、源彪、李若、李元操、盧思道、顏之推、李德林、陸乂、薛道衡、元行恭、辛德源、王劭、司馬幼之等十八人隨周武帝西行入長安。在隋朝,太子楊勇好學,引明克讓、姚察、陸開明等人為賓友。陸開明、宇文愷作《東宮典記》七十卷。
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