肽聚糖識別蛋白(英語:Peptidoglycan recognition proteinsPGRPs)是一類高度保守的模式識別受體,至少含有一個肽聚糖識別結構域,可識別細菌細胞壁肽聚糖,在昆蟲軟體動物棘皮動物脊索動物中都有存在。不同生物類群的PGRPs起的效應不同,在昆蟲中,PGRPs激活Toll等多個通路來啟動吞噬作用殺死細菌[1][2]。在哺乳動物中,PGRPs通過與細菌細胞壁的肽聚糖相互作用來殺死細菌[2]

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