白血球介素-4

白血球介素-4（白介素-4, Interleukin-4, IL-4）是II型輔助T細胞（Th2細胞）分泌的細胞因子。白血球介素-4的生物作用，包括刺活化化B細胞和T細胞增殖、 CD4+T細胞分化成II型輔助T細胞. 它也在調節體液免疫和適應性免疫中起關鍵作用。白血球介素-4誘導B細胞抗體類別轉換向IgE，上調第二型主要組織兼容性複合體的產生。這一因子是由M.霍華德、W.保羅和E. 委特塔（Vitetta）在1982共同發現的。四年後人類白血球介素-4的核苷酸序列中被分離，證實它與一小鼠蛋白B細胞刺激因子-1（BCSF-1）類似^[4].

白血球介素-4
已知的結構 PDB 直系同源搜尋: PDBe RCSB PDBID列表 1BBN、​1BCN、​1CYL、​1HIJ、​1HIK、​1HZI、​1IAR、​1ITI、​1ITL、​1ITM、​1RCB、​2B8U、​2B8X、​2B8Y、​2B8Z、​2B90、​2B91、​2CYK、​2D48、​2INT、​3BPL、​3BPN、​3QB7、​4YDY、​5FHX
識別號
別名	IL4；, Interleukin 4, IL-4
外部ID	MGI：96556 HomoloGene：491 GeneCards：IL4
基因位置（人類） 染色體 5號染色體 基因座 5q31.1 起始 132,009,678 bp 終止 132,018,370 bp
基因位置（小鼠） 染色體 小鼠11號染色體[1] 基因座 11 B1.3|11 31.97 cM 起始 53,493,809 bp[1] 終止 53,509,496 bp[1]
基因本體 分子功能 • 白血球介素-4受體結合 • 血漿蛋白結合 • 生長因子活性 • 細胞因子受體結合 • 細胞因子活性 細胞組分 • 細胞外區域 • 細胞外空間 生物學過程 • positive regulation of T cell differentiation • dendritic cell differentiation • 內皮細胞凋亡過程的負調控 • negative regulation of complement-dependent cytotoxicity • regulation of phosphorylation • negative regulation of apoptotic process • myeloid dendritic cell differentiation • type 2 immune response • B cell activation • positive regulation of interleukin-13 production • 免疫反應 • B cell differentiation • T-helper 2 cell cytokine production • regulation of isotype switching • negative regulation of transcription, DNA-templated • negative regulation of epithelial cell migration • regulation of signaling receptor activity • cholesterol metabolic process • positive regulation of B cell proliferation • positive regulation of T cell proliferation • T細胞活化 • positive regulation of MHC class II biosynthetic process • negative regulation of osteoclast differentiation • positive regulation of transcription, DNA-templated • positive regulation of transcription by RNA polymerase II • positive regulation of isotype switching to IgE isotypes • positive regulation of isotype switching to IgG isotypes • regulation of immune response • cytokine-mediated signaling pathway • positive regulation of gene expression • positive regulation of macroautophagy • positive regulation of tyrosine phosphorylation of STAT protein • activation of Janus kinase activity • positive regulation of receptor-mediated endocytosis • positive regulation of cold-induced thermogenesis • negative regulation of neuroinflammatory response • positive regulation of amyloid-beta clearance • neuroinflammatory response • positive regulation of cellular respiration • positive regulation of ATP biosynthetic process Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	3565	16189
Ensembl	ENSG00000113520	ENSMUSG00000000869
UniProt	P05112	P07750
mRNA​序列	NM_000589.4	NM_021283
蛋白序列	NP_000580 ​NP_758858 ​NP_001341919	NP_067258
基因位置​（UCSC）	Chr 5: 132.01 – 132.02 Mb	Chr 11: 53.49 – 53.51 Mb
PubMed​查找	[2]	[3]
維基數據
檢視/編輯人類 檢視/編輯小鼠

參看

• T細胞
• 輔助T細胞
• STAT6

參考文獻

1. GRCm38: Ensembl release 89: ENSMUSG00000000869 - Ensembl, May 2017
2. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Yokota et al., Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities. Proceedings of the National Academy of Sciences USA, 1986, Volume 83, pages 5894-5898.

外部連結

• MeSH|Interleukin+4 （頁面存檔備份，存於互聯網檔案館）