周璿(?—1402年),山東承宣布政使司青州府諸城縣(今山東省諸城縣)人。明朝政治人物。

洪武十七年,中舉人,並任天策衛知事。洪武三十一年,任左僉都御史。朱棣篡權後,周璿與茅大芳一同被逮捕,後不屈而亡[1][2]

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