南京教案是指明神宗萬曆四十四年(1616年),禮部侍郎南京禮部尚書沈㴶三次參奏在華天主教傳教士白蓮教有染,圖謀不軌。徐光啟上書辯護不果,其稱:「然臣累年以來,因與講究考求,知此諸臣最真最確,不止蹤跡心事一無可疑,實皆聖賢之徒也。」,七月王豐肅謝務祿(後改名曾德昭)等外國傳教士在南京被逮捕,後被押解澳門。十二月龐迪我熊三拔等人從北京被押解澳門

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