Pfitzinger反應(Pfitzinger reaction),又稱Pfitzinger-Borsche反應
靛紅與羰基化合物在鹼存在下反應得到喹啉-4-羧酸衍生物。[1][2]
![Thumb](http://upload.wikimedia.org/wikipedia/commons/thumb/b/b7/Pfitzinger_Reaction_Scheme.png/640px-Pfitzinger_Reaction_Scheme.png)
反應機理
![Thumb](http://upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Pfitzinger_Reaction_Mechanism.png/640px-Pfitzinger_Reaction_Mechanism.png)
靛紅中的酰胺鍵在鹼作用下發生水解,生成酮酸中間體(可以分離出來),它再與羰基化合物縮合為亞胺,並經互變異構,生成烯胺,最後烯胺發生分子內環化並失水,得最終產物。
變體
![Thumb](http://upload.wikimedia.org/wikipedia/commons/thumb/9/9a/Pfitzinger_Halberkann_Modification_Scheme.png/640px-Pfitzinger_Halberkann_Modification_Scheme.png)
參見
參考資料
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