LIM結構域(英語:LIM domain)是一種蛋白質結構域,由兩個疏水氨基酸殘基連接兩個鋅指結構組成[1],其命名來自於最早發現這一結構域的三種蛋白(Lin11, Isl-1 & Mec-3)的首字母[2]。LIM結構域介導蛋白質交互作用,參與細胞骨架組建,在器官發育和腫瘤發生中有重要作用。
除了關鍵氨基酸如結合鋅的半胱氨酸和中心的疏水氨基酸外,LIM結構域的氨基酸序列高度可變,其通式如下:
[C]-[X]2–4-[C]-[X]13–19-[W]-[H]-[X]2–4-[C]-[F]-[LVI]-[C]-[X]2–4-[C]-[X]13–20-C-[X]2–4-[C]
參考文獻
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