LAMA1

層沾黏蛋白亞基α1是一個層沾黏蛋白的蛋白亞基。層粘蛋白是一種組成核纖層的蛋白，在細胞核的形態維持中扮演重要角色。此蛋白質在人體內由LAMA1基因編碼^[7][8]。

LAMA1
已知的結構 PDB 直系同源搜尋: PDBe RCSB PDBID列表 2JD4
識別號
別名	LAMA1；, LAMA, S-LAM-alpha, PTBHS, Laminin, alpha 1, laminin subunit alpha 1
外部ID	OMIM：150320 MGI：99892 HomoloGene：21146 GeneCards：LAMA1
相關疾病
二型糖尿病、​ataxia-intellectual disability-oculomotor apraxia-cerebellar cysts syndrome[1]
為以下藥物的標靶
ocriplasmin[2]
基因位置（人類） 染色體 18號染色體[3] 基因座 18p11.31 起始 6,941,742 bp[3] 終止 7,117,797 bp[3]
基因位置（小鼠） 染色體 小鼠17號染色體[4] 基因座 17 E1.1|17 38.8 cM 起始 68,004,254 bp[4] 終止 68,129,642 bp[4]
RNA表達模式
查閱更多表達數據
基因本體 分子功能 • signaling receptor binding • extracellular matrix structural constituent • 血漿蛋白結合 • protein C-terminus binding • glycosphingolipid binding 細胞組分 • 細胞外間質 • 細胞外區域 • 基底膜 • laminin-1 complex • laminin-3 complex • 細胞外空間 • 膜 • cell-cell junction • laminin complex • collagen-containing extracellular matrix 生物學過程 • cell surface receptor signaling pathway • regulation of cell adhesion • 細胞粘附 • extracellular matrix organization • regulation of cell migration • regulation of embryonic development • morphogenesis of an epithelial sheet • protein phosphorylation • 組織發生 • neuron projection development • establishment of epithelial cell apical/basal polarity • retina development in camera-type eye • epithelial tube branching involved in lung morphogenesis • branching involved in salivary gland morphogenesis • retinal blood vessel morphogenesis • 軸突導向 • animal organ morphogenesis • camera-type eye development • blood vessel morphogenesis Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	284217	16772
Ensembl	ENSG00000101680	ENSMUSG00000032796
UniProt	P25391	P19137
mRNA​序列	NM_005559	NM_008480
蛋白序列	NP_005550	NP_032506
基因位置​（UCSC）	Chr 18: 6.94 – 7.12 Mb	Chr 17: 68 – 68.13 Mb
PubMed​查找	[5]	[6]
維基數據
檢視/編輯人類 檢視/編輯小鼠

相互作用

層粘蛋白亞基α1會與FBLN2（英語：FBLN2）發生蛋白質相互作用^[9][10]。

參考資料

1. 與LAMA1相關的疾病；在維基數據上查看/編輯參考.
2. 對Laminin subunit alpha 1起作用的藥物；在維基數據上查看/編輯參考.
3. GRCh38: Ensembl release 89: ENSG00000101680 - Ensembl, May 2017
4. GRCm38: Ensembl release 89: ENSMUSG00000032796 - Ensembl, May 2017
5. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
6. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
7. Nagayoshi, T.; Mattei, M. G.; Passage, E.; Knowlton, R.; Chu, M. L.; Uitto, J. Human laminin A chain (LAMA) gene: chromosomal mapping to locus 18p11.3. Genomics. 1989-11, 5 (4): 932–935 [2021-11-10]. ISSN 0888-7543. PMID 2591971. doi:10.1016/0888-7543(89)90136-5. （原始內容存檔於2021-11-10）.
8. LAMA1 laminin subunit alpha 1 [Homo sapiens (human)] - Gene - NCBI. www.ncbi.nlm.nih.gov. [2021-11-10]. （原始內容存檔於2021-11-10）.
9. Utani, A.; Nomizu, M.; Yamada, Y. Fibulin-2 binds to the short arms of laminin-5 and laminin-1 via conserved amino acid sequences. The Journal of Biological Chemistry. 1997-01-31, 272 (5): 2814–2820 [2021-11-10]. ISSN 0021-9258. PMID 9006922. doi:10.1074/jbc.272.5.2814. （原始內容存檔於2021-11-10）.
10. Talts, J. F.; Sasaki, T.; Miosge, N.; Göhring, W.; Mann, K.; Mayne, R.; Timpl, R. Structural and functional analysis of the recombinant G domain of the laminin alpha4 chain and its proteolytic processing in tissues. The Journal of Biological Chemistry. 2000-11-10, 275 (45): 35192–35199 [2021-11-10]. ISSN 0021-9258. PMID 10934193. doi:10.1074/jbc.M003261200. （原始內容存檔於2022-01-21）.

拓展閱讀

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