麥芽糖酶-葡萄糖澱粉酶

麥芽糖酶-葡萄糖澱粉酶（英語：Maltase-glucoamylase）是一種由人體 MGAM 基因編碼的酶。^[6][7]

麥芽糖酶-葡萄糖澱粉酶
已知的結構 PDB 直系同源搜尋: PDBe RCSB PDBID列表 2QLY、​2QMJ、​3CTT、​3L4T、​3L4U、​3L4V、​3L4W、​3L4X、​3L4Y、​3L4Z、​3TON、​3TOP
識別號
別名	MGAM；, MG, MGA, Maltase-glucoamylase
外部ID	OMIM：154360 MGI：1203495 HomoloGene：130099 GeneCards：MGAM
為以下藥物的標靶
米格列醇[1]
基因位置（人類） 染色體 7號染色體[2] 基因座 7q34 起始 141,907,813 bp[2] 終止 142,106,747 bp[2]
基因位置（小鼠） 染色體 小鼠6號染色體[3] 基因座 6|6 B1 起始 40,605,765 bp[3] 終止 40,746,057 bp[3]
基因本體 分子功能 • hydrolase activity, acting on glycosyl bonds • maltose alpha-glucosidase activity • hydrolase activity, hydrolyzing O-glycosyl compounds • 催化活性 • alpha-1,4-glucosidase activity • 水解酶活性 • amylase activity • glucan 1,4-alpha-glucosidase activity • carbohydrate binding • alpha-glucosidase activity 細胞組分 • integral component of membrane • 細胞膜 • apical plasma membrane • 外排體 • 膜 • tertiary granule membrane • ficolin-1-rich granule membrane 生物學過程 • polysaccharide digestion • 代謝 • starch catabolic process • maltose metabolic process • neutrophil degranulation • 碳水化合物代謝 Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	8972	232714
Ensembl	ENSG00000257335 ​ENSG00000282607	ENSMUSG00000068587
UniProt	O43451	無數據
mRNA​序列	NM_004668 ​NM_001365693	NM_001171003 ​NM_001368875
蛋白序列	NP_004659 ​NP_001352622	無數據
基因位置​（UCSC）	Chr 7: 141.91 – 142.11 Mb	Chr 6: 40.61 – 40.75 Mb
PubMed​查找	[4]	[5]
維基數據
檢視/編輯人類 檢視/編輯小鼠

麥芽糖酶-葡萄糖澱粉酶是α-葡萄糖苷酶消化酶。它由兩個具有不同基質特異性的亞基組成。 重組酶研究表明，其N-末端催化結構域對麥芽糖具有最高活性，而C-末端結構域具有更廣泛的基質特異性和對葡萄糖寡聚體的活性。^[8] 在小腸中，這種酶與蔗糖-異麥芽糖酶和α-澱粉酶協同作用，以消化各種澱粉。

延伸閱讀

• Nichols BL, Avery S, Sen P, et al. The maltase-glucoamylase gene: common ancestry to sucrase-isomaltase with complementary starch digestion activities.. Proc. Natl. Acad. Sci. U.S.A. 2003, 100 (3): 1432–7. PMC 298790 . PMID 12547908. doi:10.1073/pnas.0237170100.
• Takeshita F, Ishii KJ, Kobiyama K, et al. TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF.. Eur. J. Immunol. 2005, 35 (8): 2477–85. PMID 16052631. doi:10.1002/eji.200526151.
• Hillier LW, Fulton RS, Fulton LA, et al. The DNA sequence of human chromosome 7.. Nature. 2003, 424 (6945): 157–64. PMID 12853948. doi:10.1038/nature01782.
• Danielsen EM. Tyrosine sulfation, a post-translational modification of microvillar enzymes in the small intestinal enterocyte.. EMBO J. 1987, 6 (10): 2891–6. PMC 553723 . PMID 3121301.
• Korpela MP, Paetau A, Löfberg MI, et al. A novel mutation of the GAA gene in a Finnish late-onset Pompe disease patient: clinical phenotype and follow-up with enzyme replacement therapy.. Muscle Nerve. 2009, 40 (1): 143–8. PMID 19472353. doi:10.1002/mus.21291.
• Sim L, Quezada-Calvillo R, Sterchi EE, et al. Human intestinal maltase-glucoamylase: crystal structure of the N-terminal catalytic subunit and basis of inhibition and substrate specificity.. J. Mol. Biol. 2008, 375 (3): 782–92. PMID 18036614. doi:10.1016/j.jmb.2007.10.069.
• Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2002, 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
• Naim HY, Sterchi EE, Lentze MJ. Structure, biosynthesis, and glycosylation of human small intestinal maltase-glucoamylase.. J. Biol. Chem. 1988, 263 (36): 19709–17. PMID 3143729.
• Ao Z, Quezada-Calvillo R, Sim L, et al. Evidence of native starch degradation with human small intestinal maltase-glucoamylase (recombinant).. FEBS Lett. 2007, 581 (13): 2381–8. PMID 17485087. doi:10.1016/j.febslet.2007.04.035.
• Tuğrul S, Kutlu T, Pekin O, et al. Clinical, endocrine, and metabolic effects of acarbose, an alpha-glucosidase inhibitor, in overweight and nonoverweight patients with polycystic ovarian syndrome.. Fertil. Steril. 2008, 90 (4): 1144–8. PMID 18377903. doi:10.1016/j.fertnstert.2007.07.1326.

參考文獻

1. 對Maltase-glucoamylase起作用的藥物；在維基數據上查看/編輯參考.
2. GRCh38: Ensembl release 89: ENSG00000257335、​ENSG00000282607 - Ensembl, May 2017
3. GRCm38: Ensembl release 89: ENSMUSG00000068587 - Ensembl, May 2017
4. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
6. Entrez Gene: maltase-glucoamylase (alpha-glucosidase).
7. Nichols BL, Eldering J, Avery S, Hahn D, Quaroni A, Sterchi E. Human small intestinal maltase-glucoamylase cDNA cloning. Homology to sucrase-isomaltase. J. Biol. Chem. January 1998, 273 (5): 3076–81. PMID 9446624. doi:10.1074/jbc.273.5.3076.
8. Luminal starch substrate "brake" on maltase-glucoamylase activity is located within the glucoamylase subunit. J. Nutr. 2008, 138 (4): 685–92. PMID 18356321.