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糖蛋白激素α亞基
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糖蛋白激素α亞基(英語:Alpha subunit of glycoprotein hormones,或稱為絨毛膜促性腺激素α亞基,Glycoprotein hormones alpha chain)是一個由人類基因CGA 編碼的蛋白質[1]。
人體的四種糖蛋白激素(英語:glycoprotein hormones)--人絨毛膜促性腺激素(hCG)、黃體生成素(LH)、促卵泡激素(FSH)和促甲狀腺激素(TSH)都是以同樣的該α亞基和各自不同的β亞基組成的二聚體。[2]
此α鏈的92個氨基酸殘基的序列為:
NH2 - Ala - Pro - Asp - Val - Gln - Asp - Cys - Pro - Glu - Cys - Thr - Leu - Gln - Glu - Asn - Pro - Phe - Phe - Ser - Gln - Pro - Gly - Ala - Pro - Ile - Leu - Gln - Cys - Met - Gly - Cys - Cys - Phe - Ser - Arg - Ala - Tyr - Pro - Thr - Pro - Leu - Arg - Ser - Lys - Lys - Thr - Met - Leu - Val - Gln - Lys - Asn - Val - Thr - Ser - Glu - Ser - Thr - Cys - Cys - Val - Ala - Lys - Ser - Tyr - Asn - Arg - Val - Thr - Val - Met - Gly - Gly - Phe - Lys - Val - Glu - Asn - His - Thr - Ala - Cys - His - Cys - Ser - Thr - Cys - Tyr - Tyr - His - Lys - Ser - COOH