至高條款（Supremacy Clause）是在美國憲法第六條第二款的條款。此條款明確表示了憲法、聯邦法律及美國對外條約為「全國之最高法律」（"the supreme law of the land"）。此條款確立它們為美國法律體系的最高層次法律，強制各州法官捍衛它們，即使它們抵觸州憲法及州法律。
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This Constitution, and the Laws of the United States which shall be made in Pursuance thereof; and all Treaties made, or which shall be made, under the Authority of the United States, shall be the supreme Law of the Land; and the Judges in every State shall be bound thereby, any thing in the Constitution or Laws of any State to the Contrary notwithstanding.[1]
本憲法及依本憲法所制定之合眾國法律；以及合眾國已經締結及將要締結的一切條約，皆為全國之最高法律；每個州的法官都應受其約束，任何一州憲法或法律中的任何內容與之抵觸時，均不得有違這一規定。
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