信號轉導轉接蛋白信號轉導銜接蛋白(英語:Signal transducing adaptor proteins)是信號轉導通路中的重要蛋白質。轉接蛋白上有着各種能與其它蛋白結合的結構域,能形成各種信號複合體。這些蛋白質往往本身缺乏酶的活性[1],而是通過特異性的蛋白-蛋白交互作用形成蛋白質複合體來活化下游信號通路。常見的轉接蛋白有MyD88Grb2SHC1等。

Src相關轉接蛋白Skap2

基因

編碼轉接蛋白的基因有:

  • BCAR3 – Breast cancer anti-estrogen resistance protein 3
  • GRAP – GRB2-related adaptor protein
  • GRAP2 – GRB2-related adaptor protein 2
  • LDLRAP1 – low-density lipoprotein receptor adaptor protein 1
  • NCK1 – NCK adaptor protein 1
  • NCK2 – NCK adaptor protein 2
  • NOS1AP – nitric oxide synthase 1 (neuronal) adaptor protein
  • PIK3AP1 – phosphoinositide-3-kinase adaptor protein 1
  • SH2B1 – SH2B adaptor protein 1
  • SH2B2 – SH2B adaptor protein 2
  • SH2B3 – SH2B adaptor protein 3
  • SH2D3A -SH2 domain containing 3A
  • SH2D3C – SH2 domain containing 3C
  • SHB – Src homology 2 domain containing adaptor protein B
  • SLC4A1AP – solute carrier family 4 (anion exchanger), member 1, adaptor protein
  • GAB2 – GRB2-associated binding protein 2

參考文獻

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