Γ-麩胺醯水解酶

γ-麩胺醯水解酶（英文：Gamma-glutamyl hydrolase）是一種催化以下化學反應的酶^[5][6][7][8]：

γ-麩胺醯鍵的水解

γ-穀氨酰水解酶
命名 系統命名 縮寫
識別碼
EC編號	3.4.19.9
CAS號	9074-87-7
數據庫
IntEnz	IntEnz瀏覽
BRENDA（英語：BRENDA）	BRENDA入口
ExPASy（英語：ExPASy）	NiceZyme瀏覽
KEGG	KEGG入口
MetaCyc（英語：MetaCyc）	代謝路徑
PRIAM（英語：PRIAM_enzyme-specific_profiles）	概述
PDB	RCSB PDB PDBj PDBe PDBsum
搜索 PMC 相關文獻 PubMed 相關文獻

Γ-麩胺醯水解酶
已知的結構 PDB 直系同源搜尋: PDBe RCSB PDBID列表 1L9X
識別號
別名	GGH；, GH, gamma-glutamyl hydrolase, GATD10
外部ID	OMIM：601509 MGI：1329035 HomoloGene：2881 GeneCards：GGH
基因位置（人類） 染色體 8號染色體[1] 基因座 8q12.3 起始 63,014,881 bp[1] 終止 63,039,407 bp[1]
基因位置（小鼠） 染色體 小鼠4號染色體[2] 基因座 4|4 A3 起始 20,042,052 bp[2] 終止 20,066,750 bp[2]
RNA表達模式
查閱更多表達數據
基因本體 分子功能 • exopeptidase activity • omega peptidase activity • 水解酶活性 • gamma-glutamyl-peptidase activity 細胞組分 • 黑色素體 • 細胞質基質 • 溶酶體 • 外排體 • 細胞核 • 細胞外區域 • 細胞外空間 • azurophil granule lumen • specific granule lumen • tertiary granule lumen • 液泡 生物學過程 • response to insulin • response to zinc ion • response to ethanol • 蛋白酶解 • neutrophil degranulation • tetrahydrofolylpolyglutamate metabolic process Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	8836	14590
Ensembl	ENSG00000137563	ENSMUSG00000073987
UniProt	Q92820	Q9Z0L8
mRNA​序列	​NM_003878	NM_010281
蛋白序列	NP_003869	NP_034411
基因位置​（UCSC）	Chr 8: 63.01 – 63.04 Mb	Chr 4: 20.04 – 20.07 Mb
PubMed​查找	[3]	[4]
維基數據
檢視/編輯人類 檢視/編輯小鼠

這種溶酶體或分泌的硫醇依賴性肽酶，在酸性pH值下最活躍。

在人類中，γ-麩胺醯水解酶由GGH基因編碼。^[7][9][10]該基因通過去除γ聯聚穀氨酸和穀氨酸來催化葉酰聚-γ-穀氨酸和抗葉酰聚-γ-穀氨酸的水解。^[10]

互動通路圖

參考文獻

1. GRCh38: Ensembl release 89: ENSG00000137563 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000073987 - Ensembl, May 2017
3. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wang Y, Nimec Z, Ryan TJ, Dias JA, Galivan J. The properties of the secreted gamma-glutamyl hydrolases from H35 hepatoma cells. Biochim. Biophys. Acta. August 1993, 1164 (3): 227–35. PMID 8343522. doi:10.1016/0167-4838(93)90253-n.
6. Yao R, Rhee MS, Galivan J. Effects of gamma-glutamyl hydrolase on folyl and antifolylpolyglutamates in cultured H35 hepatoma cells. Mol. Pharmacol. September 1995, 48 (3): 505–11. PMID 7565632.
7. Yao R, Schneider E, Ryan TJ, Galivan J. Human gamma-glutamyl hydrolase: cloning and characterization of the enzyme expressed in vitro. Proc. Natl. Acad. Sci. U.S.A. September 1996, 93 (19): 10134–8. PMC 38349 . PMID 8816764. doi:10.1073/pnas.93.19.10134 .
8. Yao R, Nimec Z, Ryan TJ, Galivan J. Identification, cloning, and sequencing of a cDNA coding for rat gamma-glutamyl hydrolase. J. Biol. Chem. April 1996, 271 (15): 8525–8. PMID 8621474. doi:10.1074/jbc.271.15.8525 .
9. Yin D, Chave KJ, Macaluso CR, Galivan J, Yao R. Structural organization of the human gamma-glutamyl hydrolase gene. Gene. Dec 1999, 238 (2): 463–70. PMID 10570974. doi:10.1016/S0378-1119(99)00362-5.
10. Entrez Gene: GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase). [2022-12-12]. （原始內容存檔於2022-12-12）.

拓展閱讀

• Galivan J, Ryan T, Rhee M, et al. Glutamyl hydrolase: properties and pharmacologic impact. Semin. Oncol. 1999, 26 (2 Suppl 6): 33–7. PMID 10598552.
• O'Connor BM, Rotundo RF, Nimec Z, et al. Secretion of gamma-glutamyl hydrolase in vitro. Cancer Res. 1991, 51 (15): 3874–81. PMID 1713122.
• Chandler CJ, Wang TT, Halsted CH. Pteroylpolyglutamate hydrolase from human jejunal brush borders. Purification and characterization. J. Biol. Chem. 1986, 261 (2): 928–33. PMID 2867095. doi:10.1016/S0021-9258(17)36185-9 .
• Wang TT, Chandler CJ, Halsted CH. Intracellular pteroylpolyglutamate hydrolase from human jejunal mucosa. Isolation and characterization. J. Biol. Chem. 1986, 261 (29): 13551–5. PMID 3759978. doi:10.1016/S0021-9258(18)67054-1 .
• Yao R, Nimec Z, Ryan TJ, Galivan J. Identification, cloning, and sequencing of a cDNA coding for rat gamma-glutamyl hydrolase. J. Biol. Chem. 1996, 271 (15): 8525–8. PMID 8621474. doi:10.1074/jbc.271.15.8525 .
• Rhee MS, Lindau-Shepard B, Chave KJ, et al. Characterization of human cellular gamma-glutamyl hydrolase. Mol. Pharmacol. 1998, 53 (6): 1040–6. PMID 9614206.
• Li H, Ryan TJ, Chave KJ, Van Roey P. Three-dimensional structure of human gamma -glutamyl hydrolase. A class I glatamine amidotransferase adapted for a complex substate. J. Biol. Chem. 2002, 277 (27): 24522–9. PMID 11953431. doi:10.1074/jbc.M202020200 .
• Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899 .
• Basrur V, Yang F, Kushimoto T, et al. Proteomic analysis of early melanosomes: identification of novel melanosomal proteins. J. Proteome Res. 2003, 2 (1): 69–79. PMID 12643545. doi:10.1021/pr025562r.
• Gerhard DS, Wagner L, Feingold EA, et al. The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC). Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
• He P, Varticovski L, Bowman ED, et al. Identification of carboxypeptidase E and gamma-glutamyl hydrolase as biomarkers for pulmonary neuroendocrine tumors by cDNA microarray. Hum. Pathol. 2004, 35 (10): 1196–209 [2022-12-12]. PMID 15492986. doi:10.1016/j.humpath.2004.06.014. （原始內容存檔於2022-10-15）.
• Rual JF, Venkatesan K, Hao T, et al. Towards a proteome-scale map of the human protein-protein interaction network. Nature. 2005, 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. PMID 16189514. S2CID 4427026. doi:10.1038/nature04209.
• Eisele LE, Chave KJ, Lehning AC, Ryan TJ. Characterization of Human gamma-glutamyl hydrolase in solution demonstrates that the enzyme is a non-dissociating homodimer. Biochim. Biophys. Acta. 2006, 1764 (9): 1479–86. PMID 16945597. doi:10.1016/j.bbapap.2006.06.008.
• Chi A, Valencia JC, Hu ZZ, et al. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. J. Proteome Res. 2007, 5 (11): 3135–44. PMID 17081065. doi:10.1021/pr060363j.
• Hayashi H, Fujimaki C, Inoue K, et al. Genetic polymorphism of C452T (T127I) in human gamma-glutamyl hydrolase in a Japanese population. Biol. Pharm. Bull. 2007, 30 (4): 839–41. PMID 17409534. doi:10.1248/bpb.30.839 .

外部連結

• 醫學主題詞表（MeSH）：Gamma-glutamyl+hydrolase
• PDB中UniProt可用的所有結構資訊之概述：Q92820 (Gamma-glutamyl hydrolase) 在PDBe-KB（英語：PDBe-KB）。