可卡因的毒性,其中苯甲酰芽子碱甚至百倍剂量亦不足以产生同等毒性,但是苯甲酰芽子碱的一级代谢半衰期远高于古柯因。然而,非水解代谢产物正古柯因(英语:Norcocaine)(C₆H₅COOC₇(COOCH₃)H₁₀NH)却是一种高毒性物质,对小鼠具有比古柯因更高的毒性(半数致死剂量不足古柯因一半)。
甲卡西酮Dichloropane (RTI-111) Difluoropine FE-β-CPPIT FP-β-CPPIT Ioflupane (123I) Norcocaine WF-31 WF-11 RTI-31 RTI-32 RTI-51 RTI-112 RTI-113 RTI-120 RTI-121 (IPCIT)
ABT-202Dichloropane (RTI-111) Difluoropine FE-β-CPPIT FP-β-CPPIT Ioflupane (123I) Norcocaine WF-31 WF-11 RTI-31 RTI-32 RTI-51 RTI-112 RTI-113 RTI-120 RTI-121 (IPCIT)
1-(3-甲基苄基)哌嗪Dichloropane (RTI-111) Difluoropine FE-β-CPPIT FP-β-CPPIT Ioflupane (123I) Norcocaine WF-31 WF-11 RTI-31 RTI-32 RTI-51 RTI-112 RTI-113 RTI-120 RTI-121 (IPCIT)
5-MeO-DiPTDichloropane (RTI-111) Difluoropine FE-β-CPPIT FP-β-CPPIT Ioflupane (123I) Norcocaine WF-31 WF-11 RTI-31 RTI-32 RTI-51 RTI-112 RTI-113 RTI-120 RTI-121 (IPCIT)