II型干擾素只有干擾素伽瑪(干擾素-γ, Interferon-γ)一個成員。 成熟的干擾素伽瑪蛋白是反平行二聚體,可以與結合到干擾素伽瑪受體(IFNGR),干擾素伽瑪受體由兩個亞基組成。

Quick Facts II型干擾素 (γ), 鑑定 ...
II型干擾素 (γ)
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鑑定
標誌IFN-gamma
PfamPF00714舊版
InterPro英語InterProIPR002069
CATH1d9cA00
SCOP英語Structural Classification of Proteinsd1d9ca_ / SUPFAM
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來源

干擾素伽瑪是由活化T細胞自然殺傷細胞(NK細胞)產生的。 在輔助T細胞中,I型輔助T細胞(Th1細胞)釋放干擾素伽瑪;II型輔助T細胞(Th2細胞)釋放白細胞介素-4 (IL-4) 和白細胞介素-13 (IL-13)。

功能

干擾素伽瑪參與調節免疫和炎症反應;

  • 干擾素伽瑪的有一定的抗病毒作用,但很微弱;
  • 干擾素伽瑪的有一定的抗腫瘤作用,也很微弱;
  • 干擾素伽瑪參與調節I型干擾素的免疫功能;
  • 干擾素伽瑪徵集白細胞到感染局部,因而調節炎性反應;
  • 干擾素伽瑪激發巨噬細胞的殺菌能力;
  • 干擾素伽瑪調節II型輔助T細胞(Th2細胞)的免疫功能;
  • 干擾素伽瑪的表達異常或使用不當,可能導致自體免疫性疾病

參考文獻

  • Kosmidis C., Sapalidis K., Koletsa T., Kosmidou M., Efthimiadis C. and Anthimidis G. (2018). Interferon-γ and Colorectal Cancer: an up-to date. Journal of Cancer, 9(2), 232-238.
  • Young, H. A. (1996) Regulation of interferon-gamma gene expression. J. Interferon Cytokine Res. 16, 563–568.
  • Frucht, D. M., Fukao, T., Bogdan, C., Schindler, H., O'Shea, J. J., Koyasu, S. (2001) IFN-gamma production by antigen-presenting cells: mechanisms emerge. Trends Immunol. 22, 556–560.
  • Gessani, S., Belardelli, F. (1998) IFN-gamma expression in macrophages and its possible biological significance. Cytokine Growth Factor Rev. 9, 117–123
  • Schroder K., Hertzog P.J., Ravasi T. and Hume D. A. (2004) Interferon-: an overview of signals, mechanisms and functions. Journal of Leukocyte Biology, 75(2), 163-189.

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