骨質軟化（英語：Osteomalacia）又稱軟骨病，是一種因骨骼代謝障礙而引起的骨骼軟化疾病，引起骨骼代謝障礙的原因有人體缺乏磷酸鹽、鈣和維生素D，或是鈣的骨質吸收作用。兒童要是出現骨質疏鬆則稱為佝僂病，正因為如此，骨質疏鬆症這一稱呼常用於程度較輕的成人患者。骨質軟化的症狀和體徵有身體出現瀰漫性疼痛、肌肉無力和脆弱的骨骼[1][2][3][4][5]。及時補充維生素D和鈣可以預防和治療骨質軟化[6]。
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