聖地牙哥省（西班牙語：Provincia de Santiago）是智利聖地牙哥首都大區的一個省，總面積2109.7平方公里。總人口4728,443，人口密度2241.3人/平方公里。聖地牙哥省包含32個市鎮。聖地牙哥省的產值佔全國的30%。該省為大陸性氣候，年降水量367毫米。
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