卡莫司他(英語:camostat,開發代碼FOY-305),是一種絲氨酸蛋白酶抑制劑,在體內有各種功能。被用來治療某些腫瘤,並被用來有效地抵抗病毒感染。還可抑制肝臟纖維化、腎病或胰腺炎。[1][2][3][4][5]在日本被批准使用。[6]
2020年德國科學家在細胞雜誌上發表論文指出甲磺酸卡莫司他(英語:camostat mesylate)積極對抗TMPRSS2,部分阻斷SARS-2-S-驅動的進入Caco-2和Vero195 TMPRSS2細胞。[7]
Quick Facts 臨床資料, 商品名(英語:Drug nomenclature) ...
卡莫司他 |
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商品名 | Foipan |
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AHFS/Drugs.com | 國際藥品名稱 |
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給藥途徑 | Oral |
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ATC碼 | |
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法律規範 |
- 美:Not FDA approved
- 處方藥(℞-only)
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N,N-Dimethylcarbamoylmethyl 4-(4-guanidinobenzoyloxy)phenylacetate
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CAS號 | 59721-28-7 Y |
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PubChem CID | |
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IUPHAR/BPS | |
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ChemSpider | |
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UNII | |
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ChEMBL | |
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CompTox Dashboard (EPA) | |
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化學式 | C20H22N4O5 |
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摩爾質量 | 398.42 g·mol−1 |
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3D模型(JSmol) | |
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CN(C)C(=O)COC(=O)CC1=CC=C(C=C1)OC(=O)C2=CC=C(C=C2)N=C(N)N
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InChI=1S/C20H22N4O5/c1-24(2)17(25)12-28-18(26)11-13-3-9-16(10-4-13)29-19(27)14-5-7-15(8-6-14)23-20(21)22/h3-10H,11-12H2,1-2H3,(H4,21,22,23) YKey:XASIMHXSUQUHLV-UHFFFAOYSA-N Y
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Zhou, Y.; Vedantham, P.; Lu, K.; Agudelo, J.; Carrion Jr, R.; Nunneley, J. W.; Barnard, D.; Pöhlmann, S.; McKerrow, J. H.; Renslo, A. R.; Simmons, G. Protease inhibitors targeting coronavirus and filovirus entry. Antiviral Research. 2015, 116: 76–84. PMC 4774534 . PMID 25666761. doi:10.1016/j.antiviral.2015.01.011.
Ueda, M.; Uchimura, K.; Narita, Y.; Miyasato, Y.; Mizumoto, T.; Morinaga, J.; Hayata, M.; Kakizoe, Y.; Adachi, M.; Miyoshi, T.; Shiraishi, N.; Kadowaki, D.; Sakai, Y.; Mukoyama, M.; Kitamura, K. The serine protease inhibitor camostat mesilate attenuates the progression of chronic kidney disease through its antioxidant effects. Nephron. 2015, 129 (3): 223–32. PMID 25766432. doi:10.1159/000375308.