糖蛋白激素α亞基

糖蛋白激素α亞基（英語：Alpha subunit of glycoprotein hormones，或稱為絨毛膜促性腺激素α亞基，Glycoprotein hormones alpha chain）是一個由人類基因CGA 編碼的蛋白質^[1]。

Glycoprotein hormones, alpha polypeptide 絨毛膜促性腺激素，α多肽
PDB rendering based on 1dz7.
有效結構 PDB 直系同源檢索：PDBe, RCSB PDB查詢代碼列表 1DZ7, 1E9J, 1FL7, 1HCN, 1HD4, 1HRP, 1QFW, 1XWD, 4AY9
標識
代號	CGA; CG-ALPHA; FSHA; GPHA1; GPHa; HCG; LHA; TSHA
擴展標識	遺傳學：118850 鼠基因：88390 同源基因：587 GeneCards: CGA Gene
基因本體論描述 分子功能 · hormone activity · protein binding 細胞成分 · extracellular region 生物過程 · thyroid hormone generation · signal transduction · cell-cell signaling · positive regulation of cell proliferation · gonad development · peptide hormone processing · positive regulation of cell migration · thyroid gland development · luteinizing hormone secretion · cellular response to hormone stimulus · cellular protein metabolic process · positive regulation of transcription from RNA polymerase II promoter · negative regulation of organ growth · follicle-stimulating hormone secretion · developmental growth Sources: Amigo / QuickGO
RNA表達模式
更多表達數據
直系同源體
物種	人類	小鼠
Entrez	1081	12640
Ensembl	ENSG00000135346	ENSMUSG00000028298
UniProt	P01215	P01216
mRNA序列	NM_000735	NM_009889
蛋白序列	NP_000726	NP_034019
基因位置	Chr 6: 87.8 – 87.8 Mb	Chr 4: 34.89 – 34.91 Mb
PubMed查詢	[1]	[2]
閱 論 編

人體的四種糖蛋白激素（英語：glycoprotein hormones）--人絨毛膜促性腺激素（hCG）、黃體生成素（LH）、促卵泡激素（FSH）和促甲狀腺激素（TSH）都是以同樣的該α亞基和各自不同的β亞基組成的二聚體。^[2]

此α鏈的92個氨基酸殘基的序列為：

NH₂ - Ala - Pro - Asp - Val - Gln - Asp - Cys - Pro - Glu - Cys - Thr - Leu - Gln - Glu - Asn - Pro - Phe - Phe - Ser - Gln - Pro - Gly - Ala - Pro - Ile - Leu - Gln - Cys - Met - Gly - Cys - Cys - Phe - Ser - Arg - Ala - Tyr - Pro - Thr - Pro - Leu - Arg - Ser - Lys - Lys - Thr - Met - Leu - Val - Gln - Lys - Asn - Val - Thr - Ser - Glu - Ser - Thr - Cys - Cys - Val - Ala - Lys - Ser - Tyr - Asn - Arg - Val - Thr - Val - Met - Gly - Gly - Phe - Lys - Val - Glu - Asn - His - Thr - Ala - Cys - His - Cys - Ser - Thr - Cys - Tyr - Tyr - His - Lys - Ser - COOH