乳清酸核苷-5'-磷酸脫羧酶(英語:Orotidine 5'-phosphate decarboxylase,縮寫ODCase,簡稱OMP脫羧酶,OMP decarboxylase,或乳清苷酸脫羧酶orotidylate decarboxylase) 是嘧啶生物合成過程中的一種酶,催化單磷酸乳清苷(OMP)的脫羧反應生成單磷酸尿苷(UMP)。這一過程是嘧啶核苷酸的「從頭合成」(de novo)中不可缺少的一步。OMP脫羧酶具有極高的催化效率,也作為酵母菌株工程篩選指標。
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