鎖核酸（Locked nucleic acid，LNA）是一種經過修飾的RNA，LNA中一部分核糖上的2'與4'碳連結在一起。一般可見於A-DNA或RNA。
這類核酸可以增加引子或探針（probe）的融解溫度（Tm值），加強這些實驗用物質的穩定性，可應用在即時聚合酶連鎖反應（real-time PCR）等技術中。
參考文獻
- Kaur, H.; Arora, A.; Wengel, J.; Maiti, S. Thermodynamic, Counterion, and Hydration Effects for the Incorporation of Locked Nucleic Acid Nucleotides into DNA Duplexes. Biochemistry. 2006, 45 (23): 7347–55. doi:10.1021/bi060307w.
外部連結
- A predictor for the physical properties of LNA modified oligonucleotides
- LNA (locked nucleic acid): high-affinity targeting of complementary RNA and DNA （頁面存檔備份，存於互聯網檔案館）
- LNA: a versatile tool for therapeutics and genomics （頁面存檔備份，存於互聯網檔案館）
- Alternative Nucleic Acid Analogues for Programmable Assembly: Hybridization of LNA to PNA （頁面存檔備份，存於互聯網檔案館）
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