他先後在 Siponto總教區,Sapina和弗拉斯卡蒂兩個羅馬城郊教區任主教。1455年選舉Alonso de Borgia為新教宗嘉禮三世時,因對羅馬奧爾西尼家族和科隆納家族兩大家族人選之間的競爭並不感興趣,而使他成了另一候選。由於他的希臘背景,受到法國樞機Alain de Coëtivy的反對。「樞機們害怕的未必是他的希臘式的培養或者他的性格,而是他的禁欲主義和改革教會的熱誠。」(Francis A. Burkle-Young)
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