中醫專著《黃帝內經·上古天真論篇第一》記載:「中古之時，有至人者，淳德全道，和於陰陽，調於四時，去世離俗，積精全神，遊行天地之間，視聽八遠之外，此蓋益其壽命而強者也。亦歸於真人。」莊子中也有至人之用心如鏡不將不迎的說法。
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