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熱脫硫桿菌科（學名：Thermodesulfobacteriaceae）為熱脫硫桿菌目的唯一一科。此科的模式屬為熱脫硫桿菌屬(Thermodesulfobacterium)。
- Caldimicrobium Miroshnichenko et al. 2009
- Thermodesulfatator Moussard et al. 2004
- 熱脫硫桿菌屬 Thermodesulfobacterium Zeikus et al. 1995
- Thermosulfurimonas Slobodkin et al. 2012
- LPSN - List of Prokaryotic names with Standing in Nomenclature
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