異檸檬酸脫氫酶 (NAD+)(英語:isocitrate dehydrogenase (NAD+),EC 1.1.1.41 (頁面存檔備份,存於互聯網檔案館))是一種以NAD+或NADP+為受體、作用於供體CH-OH基團上的氧化還原酶。這種酶能催化以下酶促反應:
- 異檸檬酸 + NAD+ 2-酮戊二酸 + CO2 + NADH
Quick Facts +), 命名 ...
異檸檬酸脫氫酶 (NAD+)
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結合了檸檬酸(洋紅色小分子)和NAD+(白色)的異檸檬酸脫氫酶 (NAD+)[1](PDB 3blv)
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命名
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系統命名
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isocitrate:NAD+ oxidoreductase (decarboxylating)
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縮寫
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IDH(有歧義)
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別名
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isocitric dehydrogenase; β-ketoglutaric-isocitric carboxylase; isocitric acid dehydrogenase; NAD dependent isocitrate dehydrogenase; NAD isocitrate dehydrogenase; NAD-linked isocitrate dehydrogenase; NAD-specific isocitrate dehydrogenase; NAD isocitric dehydrogenase; isocitrate dehydrogenase (NAD); nicotinamide adenine dinucleotide isocitrate dehydrogenase
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識別碼
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EC編號
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1.1.1.41
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CAS號
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9001-58-5
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數據庫
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IntEnz
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IntEnz瀏覽
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BRENDA
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BRENDA入口
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ExPASy
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NiceZyme瀏覽
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KEGG
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KEGG入口
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MetaCyc
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代謝路徑
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PRIAM
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概述
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PDB
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RCSB PDB PDBj PDBe PDBsum
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基因本體
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AmiGO / EGO
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異檸檬酸脫氫酶 (NAD+)需要二價錳離子(Mn2+)或二價鎂離子(Mg2+)以維持活性。真核細胞中的異檸檬酸脫氫酶 (NAD+)以兩種形式存在:其中一種與NAD+相關聯且僅在線粒體中被發現並可以變構調節;另一種與NADP+還存在於細胞質基質中但不能變構調節。[2] 這兩種酶——異檸檬酸脫氫酶 (NAD+)與異檸檬酸脫氫酶 (NADP+)並不相同,後者不能以草酰琥珀酸作為底物。某些物種的異檸檬酸脫氫酶 (NAD+)也能利用NADP+,但催化的反應速率較慢。[3]
A. D. Mesecar, B. L. Stoddard, D. E. Koshland. Orbital steering in the catalytic power of enzymes: small structural changes with large catalytic consequences.. Science. 1997, 277: 202–206.
Inoue, H., Tamura, T., Ehara, N., Nishito, A., Nakayama, Y., Maekawa, M., Imada, K., Tanaka, H. and Inagaki, K. Biochemical and molecular characterization of the NAD+-dependent isocitrate dehydrogenase from the chemolithotroph Acidithiobacillus thiooxidans.. FEMS Microbiol. Lett. 2002, 214: 127–132 [2012-05-08]. PMID 12204383. (原始內容存檔於2019-03-23) (英語).
- Hathaway, J.A. and Atkinson, D.E. The effect of adenylic acid on yeast nicotinamide adenine dinucleotide isocitrate dehydrogenase, a possible metabolic control mechanism.. J. Biol. Chem. 1963, 238: 2875–2881 [2012-05-08]. PMID 14063317. (原始內容存檔於2019-03-25) (英語).
- Kornberg, A. and Pricer, W.E. Di- and triphosphopyridine nucleotide isocitric dehydrogenase in yeast.. J. Biol. Chem. 1951, 189: 123–136 [2012-05-08]. PMID 14832224. (原始內容存檔於2019-03-22) (英語).
- Plaut, G.W.E. Isocitrate dehydrogenases. Lardy, H. and Myrbäck, K. (編). The Enzymes 7 2nd. New York: Academic Press. 1963: 105–126 (英語).
- Plaut, G.W.E. and Sung, S.-C. Diphosphopyridine nucleotide isocitric dehydrogenase from animal tissues. J. Biol. Chem. 207: 305–314. 1954 [2012-05-08]. PMID 13152105. (原始內容存檔於2019-03-25) (英語).
- Ramakrishnan, C.V. and Martin, S.M. Isocitric dehydrogenase in Aspergillus niger. 55. 1955: 403–407 (英語).
- Vickery, H.B. A suggested new nomenclature for the isomers of isocitric acid.. J. Biol. Chem.: 1739–1741. [2012-05-08]. PMID 13925783. (原始內容存檔於2019-03-23) (英語).
- Kim, Y.O., Koh, H.J., Kim, S.H., Jo, S.H., Huh, J.W., Jeong, K.S., Lee, I.J., Song, B.J. and Huh, T.L. Identification and functional characterization of a novel, tissue-specific NAD+-dependent isocitrate dehydrogenase β subunit isoform.. J. Biol. Chem. 1999, 274: 36866–36875 [2012-05-08]. PMID 10601238. (原始內容存檔於2019-03-22) (英語).