去氧核糖核酸外切酶（英語：exodeoxyribonuclease，或稱外切去氧核糖核酸酶）是一類可參與切割DNA分子的酶，屬於EC3.1.11。是一種酯酶。它會產生5'-磷酸鹽作為反應副產品。[1]
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