核苷類逆轉錄酶抑制劑（英語：Nucleoside Reverse Transcriptase Inhibitors，簡稱NRTIs），是合成HIV的DNA逆轉錄酶底物脫氧核苷酸的類似物，在體內轉化成活性的三磷酸核苷衍生物，與天然的三磷酸脫氧核苷競爭性與HIV逆轉錄酶（RT）結合，抑制RT的作用，阻礙前病毒的合成。
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