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硫化葉菌科 （學名：Sulfolobaceae）為硫化葉菌目的一科細菌。此科的模式屬為硫化葉菌屬(Sulfolobus)。
本科包括以下屬：
- 嗜酸兩面菌屬 Acidianus Segerer et al. 1986
- Desulfurolobus Zillig and Böck 1987，異名
- 金屬球菌屬 Metallosphaera Huber et al. 1989
- Saccharolobus Sakai and Kurosawa 2018
- 棲冥河菌屬 Stygiolobus Segerer et al. 1991
- Sulfodiicoccus Sakai and Kurosawa 2017
- 硫化葉菌屬 Sulfolobus Brock et al. 1972
- Sulfuracidifex Itoh et al. 2020
- 硫代謝球菌屬 Sulfurisphaera Kurosawa et al. 1998
- 硫化球菌屬 Sulfurococcus Golovacheva et al. 1995
- LPSN - List of Prokaryotic names with Standing in Nomenclature
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