在南齊任太子舍人，南梁時為吳興令。篤信佛法，曾與范縝在神滅論論戰中針鋒相對。王琰痛斥范縝：「嗚呼范子！曾不知其先祖神靈所在。」范縝回道：「嗚呼王子！知其先祖神靈所在，而不能殺身以從之。」著有《冥祥記》10卷[1]，已佚。《古小說鉤沉》輯錄一百三十一條。
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