生平
蔡萊是天啟元年（1621年）辛酉科江西鄉試舉人[2]，授上饒教諭，得福建巡撫推薦擢福州同知，當時鄭芝龍盤踞海上，他到任後寫信切責，鄭芝龍婉言辭謝，拿出珍玩作餽贈但被他推卻不受，使鄭芝龍畏懼，同時他在外招安，內修戰具，不久署理知府篆務，並護理福州兵備道僉事事，擅於鎮撫，海寇不敢侵犯，又曾代民償還積欠，釋放無辜囚犯，福州人都感激他，因病吿歸[1][3]。
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