早幼粒細胞白血病蛋白

早幼粒細胞白血病蛋白是指可能的轉錄因子可能的轉錄因子（英語：Probable transcription factor PML），是一個由人類基因 PML 編碼的抑癌蛋白。

Promyelocytic leukemia 早幼粒細胞白血病蛋白
PDB rendering based on 1bor.
有效結構 PDB 直系同源檢索：PDBe, RCSB PDB查詢代碼列表 1BOR
標識
代號	PML; MYL; PP8675; RNF71; TRIM19
擴展標識	遺傳學：102578 鼠基因：104662 同源基因：13245 GeneCards: PML Gene
基因本體論描述 分子功能 · DNA binding · transcription coactivator activity · protein binding · zinc ion binding · ubiquitin protein ligase binding · SUMO binding · protein homodimerization activity · SMAD binding · protein heterodimerization activity · cobalt ion binding 細胞成分 · nucleus · nucleoplasm · nucleolus · cytoplasm · cytosol · nuclear matrix · PML body · early endosome membrane · nuclear membrane · extrinsic component of endoplasmic reticulum membrane 生物過程 · response to hypoxia · regulation of protein phosphorylation · positive regulation of defense response to virus by host · transcription, DNA-templated · regulation of transcription, DNA-templated · protein complex assembly · protein targeting · apoptotic process · activation of cysteine-type endopeptidase activity involved in apoptotic process · DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest · cell cycle arrest · transforming growth factor beta receptor signaling pathway · common-partner SMAD protein phosphorylation · SMAD protein import into nucleus · negative regulation of cell proliferation · intrinsic apoptotic signaling pathway in response to DNA damage · intrinsic apoptotic signaling pathway in response to oxidative stress · response to UV · response to gamma radiation · regulation of calcium ion transport into cytosol · viral process · negative regulation of angiogenesis · cytokine-mediated signaling pathway · myeloid cell differentiation · negative regulation of cell growth · PML body organization · positive regulation of histone deacetylation · negative regulation of telomere maintenance via telomerase · endoplasmic reticulum calcium ion homeostasis · circadian regulation of gene expression · negative regulation of translation in response to oxidative stress · response to cytokine · regulation of circadian rhythm · intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator · entrainment of circadian clock by photoperiod · proteasome-mediated ubiquitin-dependent protein catabolic process · innate immune response · cell fate commitment · regulation of MHC class I biosynthetic process · negative regulation of transcription, DNA-templated · negative regulation of mitotic cell cycle · retinoic acid receptor signaling pathway · protein stabilization · maintenance of protein location in nucleus · defense response to virus · negative regulation of telomerase activity · positive regulation of apoptotic process involved in mammary gland involution · interferon-gamma-mediated signaling pathway · branching involved in mammary gland duct morphogenesis · intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress · cellular response to interleukin-4 · cellular senescence · extrinsic apoptotic signaling pathway · negative regulation of viral release from host cell · negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process · regulation of double-strand break repair · positive regulation of extrinsic apoptotic signaling pathway Sources: Amigo / QuickGO
直系同源體
物種	人類	小鼠
Entrez	5371	18854
Ensembl	ENSG00000140464	ENSMUSG00000036986
UniProt	P29590	Q60953
mRNA序列	NM_002675	NM_008884
蛋白序列	NP_002666	NP_032910
基因位置	Chr 15: 74.29 – 74.34 Mb	Chr 9: 58.22 – 58.25 Mb
PubMed查詢	[1]	[2]
閱 論 編

功能

互作

早幼粒細胞白血病蛋白可與下列蛋白質發生交互作用：

• ANKRD2,^[1]
• CREB-binding protein,^[2][3][4]
• Cyclin T1,^[5]
• Death associated protein 6,^[6][7][8][9]
• GATA2,^[10]
• HDAC1,^[11][12]
• HDAC3,^[12]
• HHEX,^[13]
• MAPK11,^[14]
• MYB,^[15]
• Mdm2,^{[16][17][18][19]}
• Nerve Growth factor IB,^[20]
• Nuclear receptor co-repressor 1,^[11]
• Nuclear receptor co-repressor 2,^[11][21]
• P53,^[16][22][23]
• RPL11,^[17]
• 視網膜母細胞瘤蛋白^[24]
• 視黃酸受體α,^[2]
• SIN3A,^[11]
• SKI protein,^[11]
• STAT3,^[25]
• Serum response factor^[3]and
• Small ubiquitin-related modifier 1,^[26][27]
• Sp1 transcription factor,^[28]
• TOPBP1,^[29]
• Thymine-DNA glycosylase,^[30]and
• Zinc finger and BTB domain-containing protein 16.^[31]

參見

• RING finger domain

參考文獻

1. Kojic, Snezana; Medeot, Elisa; Guccione, Ernesto; Krmac, Helena; Zara, Ivano; Martinelli, Valentina; Valle, Giorgio; Faulkner, Georgine. The Ankrd2 Protein, a Link Between the Sarcomere and the Nucleus in Skeletal Muscle. Journal of Molecular Biology. 2004-05, 339 (2) [2022-06-16]. doi:10.1016/j.jmb.2004.03.071. （原始內容存檔於2022-06-15） （英語）.
2. Zhong, Sue; Delva, Laurent; Rachez, Christophe; Cenciarelli, Cristina; Gandini, Domenica; Zhang, Hui; Kalantry, Sundeep; Freedman, Leonard P.; Pandolfi, Pier Paolo. A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARα and T18 oncoproteins. Nature Genetics. 1999-11, 23 (3) [2022-06-16]. ISSN 1061-4036. PMID 10610177. doi:10.1038/15463. （原始內容存檔於2022-03-10） （英語）.
3. Matsuzaki, Kazuhito; Minami, Takeshi; Tojo, Masahide; Honda, Yoshiomi; Saitoh, Noriko; Nagahiro, Shinji; Saya, Hideyuki; Nakao, Mitsuyoshi. PML-nuclear bodies are involved in cellular serum response. Genes to Cells: Devoted to Molecular & Cellular Mechanisms. 2003-03, 8 (3) [2022-06-16]. ISSN 1356-9597. PMID 12622724. doi:10.1046/j.1365-2443.2003.00632.x. （原始內容存檔於2022-06-16）.
4. Doucas, Vassilis; Tini, Marc; Egan, David A.; Evans, Ronald M. Modulation of CREB binding protein function by the promyelocytic (PML) oncoprotein suggests a role for nuclear bodies in hormone signaling. Proceedings of the National Academy of Sciences. 1999-03-16, 96 (6) [2022-06-16]. ISSN 0027-8424. PMC 15819 . PMID 10077561. doi:10.1073/pnas.96.6.2627. （原始內容存檔於2022-06-16） （英語）.
5. Marcello, A. Recruitment of human cyclin T1 to nuclear bodies through direct interaction with the PML protein. The EMBO Journal. 2003-05-01, 22 (9). PMC 156077 . PMID 12727882. doi:10.1093/emboj/cdg205.
6. Ishov, Alexander M.; Sotnikov, Alexey G.; Negorev, Dmitri; Vladimirova, Olga V.; Neff, Norma; Kamitani, Tetsu; Yeh, Edward T.H.; Strauss, Jerome F.; Maul, Gerd G. Pml Is Critical for Nd10 Formation and Recruits the Pml-Interacting Protein Daxx to This Nuclear Structure When Modified by Sumo-1. Journal of Cell Biology. 1999-10-18, 147 (2) [2022-06-16]. ISSN 0021-9525. PMC 2174231 . PMID 10525530. doi:10.1083/jcb.147.2.221. （原始內容存檔於2022-06-16） （英語）.
7. Li, Hui; Leo, Christopher; Zhu, Jiang; Wu, Xiaoyang; O'Neil, Jennifer; Park, Eun-Ju; Chen, J. Don. Sequestration and Inhibition of Daxx-Mediated Transcriptional Repression by PML. Molecular and Cellular Biology. 2000-03, 20 (5) [2022-06-16]. ISSN 0270-7306. PMC 85360 . PMID 10669754. doi:10.1128/MCB.20.5.1784-1796.2000. （原始內容存檔於2021-11-28） （英語）.
8. Lehembre, François; Müller, Stefan; Pandolfi, Pier Paolo; Dejean, Anne. Regulation of Pax3 transcriptional activity by SUMO-1-modified PML. Oncogene. 2001-01-04, 20 (1) [2022-06-16]. ISSN 0950-9232. PMID 11244500. doi:10.1038/sj.onc.1204063. （原始內容存檔於2021-08-11） （英語）.
9. Zhong, Sue; Salomoni, Paolo; Ronchetti, Simona; Guo, Ailan; Ruggero, Davide; Pandolfi, Pier Paolo. Promyelocytic Leukemia Protein (Pml) and Daxx Participate in a Novel Nuclear Pathway for Apoptosis. Journal of Experimental Medicine. 2000-02-21, 191 (4) [2022-06-16]. ISSN 0022-1007. PMC 2195846 . PMID 10684855. doi:10.1084/jem.191.4.631. （原始內容存檔於2022-06-16） （英語）.
10. Tsuzuki, Shinobu; Towatari, Masayuki; Saito, Hidehiko; Enver, Tariq. Potentiation of GATA-2 Activity through Interactions with the Promyelocytic Leukemia Protein (PML) and the t(15;17)-Generated PML-Retinoic Acid Receptor α Oncoprotein. Molecular and Cellular Biology. 2000-09, 20 (17) [2022-06-16]. ISSN 0270-7306. PMC 86102 . PMID 10938104. doi:10.1128/MCB.20.17.6276-6286.2000. （原始內容存檔於2022-06-16） （英語）.
11. Khan, M. M.; Nomura, T.; Kim, H.; Kaul, S. C.; Wadhwa, R.; Shinagawa, T.; Ichikawa-Iwata, E.; Zhong, S.; Pandolfi, P. P.; Ishii, S. Role of PML and PML-RARalpha in Mad-mediated transcriptional repression. Molecular Cell. 2001-06, 7 (6) [2022-06-16]. ISSN 1097-2765. PMID 11430826. doi:10.1016/s1097-2765(01)00257-x. （原始內容存檔於2021-11-28）.
12. Wu, Wen-Shu; Vallian, Sadeq; Seto, Edward; Yang, Wen-Ming; Edmondson, Diane; Roth, Sharon; Chang, Kun-Sang. The Growth Suppressor PML Represses Transcription by Functionally and Physically Interacting with Histone Deacetylases. Molecular and Cellular Biology. 2001-04, 21 (7) [2022-06-16]. ISSN 0270-7306. PMC 86860 . PMID 11259576. doi:10.1128/MCB.21.7.2259-2268.2001. （原始內容存檔於2022-06-16） （英語）.
13. Topcu, Zeki; Mack, David L; Hromas, Robert A; Borden, Katherine LB. The promyelocytic leukemia protein PML interacts with the proline-rich homeodomain protein PRH: a RING may link hematopoiesis and growth control. Oncogene. 1999-11-25, 18 (50) [2022-06-16]. ISSN 0950-9232. PMID 10597310. doi:10.1038/sj.onc.1203201. （原始內容存檔於2022-06-16） （英語）.
14. Shin, Jinwook; Park, Boyoun; Cho, Sunglim; Lee, Sunray; Kim, Youngkyun; Lee, Seong-Ok; Cho, Kwangmin; Lee, Sungwook; Jin, Bong-Suk; Ahn, Jin-Hyun; Choi, Eui-Ju. Promyelocytic leukemia is a direct inhibitor of SAPK2/p38 mitogen-activated protein kinase. The Journal of Biological Chemistry. 2004-09-24, 279 (39) [2022-06-16]. ISSN 0021-9258. PMID 15273249. doi:10.1074/jbc.M407369200. （原始內容存檔於2022-06-16）.
15. Dahle, Øyvind; Bakke, Oddmund; Gabrielsen, Odd Stokke. c-Myb associates with PML in nuclear bodies in hematopoietic cells. Experimental Cell Research. 2004-07-01, 297 (1) [2022-06-16]. ISSN 0014-4827. PMID 15194430. doi:10.1016/j.yexcr.2004.03.014. （原始內容存檔於2022-06-16）.
16. Kurki, Sari; Latonen, Leena; Laiho, Marikki. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. Journal of Cell Science. 2003-10-01, 116 (19) [2022-06-16]. ISSN 1477-9137. PMID 12915590. doi:10.1242/jcs.00714. （原始內容存檔於2022-06-16） （英語）.
17. Bernardi, Rosa; Scaglioni, Pier Paolo; Bergmann, Stephan; Horn, Henning F.; Vousden, Karen H.; Pandolfi, Pier Paolo. PML regulates p53 stability by sequestering Mdm2 to the nucleolus. Nature Cell Biology. 2004-07, 6 (7) [2022-06-16]. ISSN 1465-7392. PMID 15195100. doi:10.1038/ncb1147. （原始內容存檔於2022-06-17） （英語）.
18. Zhu, Hongyan; Wu, Liqing; Maki, Carl G. MDM2 and promyelocytic leukemia antagonize each other through their direct interaction with p53. The Journal of Biological Chemistry. 2003-12-05, 278 (49) [2022-06-16]. ISSN 0021-9258. PMID 14507915. doi:10.1074/jbc.M308302200. （原始內容存檔於2022-06-16）.
19. Wei, Xiaolong; Yu, Zhong Kang; Ramalingam, Arivudainambi; Grossman, Steven R.; Yu, Jiang H.; Bloch, Donald B.; Maki, Carl G. Physical and functional interactions between PML and MDM2. The Journal of Biological Chemistry. 2003-08-01, 278 (31) [2022-06-16]. ISSN 0021-9258. PMID 12759344. doi:10.1074/jbc.M212215200. （原始內容存檔於2022-06-16）.
20. Wu, Wen-Shu; Xu, Zhi-Xiang; Ran, Ruixiang; Meng, Feng; Chang, Kun-Sang. Promyelocytic leukemia protein PML inhibits Nur77-mediated transcription through specific functional interactions. Oncogene. 2002-05-30, 21 (24) [2022-06-16]. ISSN 0950-9232. PMID 12032831. doi:10.1038/sj.onc.1205491. （原始內容存檔於2022-06-16） （英語）.
21. Hong, Suk-Hyun; Yang, Zhihong; Privalsky, Martin L. Arsenic Trioxide Is a Potent Inhibitor of the Interaction of SMRT Corepressor with Its Transcription Factor Partners, Including the PML-Retinoic Acid Receptor α Oncoprotein Found in Human Acute Promyelocytic Leukemia. Molecular and Cellular Biology. 2001-11, 21 (21) [2022-06-16]. ISSN 0270-7306. PMC 99892 . PMID 11585900. doi:10.1128/MCB.21.21.7172-7182.2001. （原始內容存檔於2021-08-11） （英語）.
22. Fogal, V. Regulation of p53 activity in nuclear bodies by a specific PML isoform. The EMBO Journal. 2000-11-15, 19 (22). PMC 305840 . PMID 11080164. doi:10.1093/emboj/19.22.6185.
23. Guo, Ailan; Salomoni, Paolo; Luo, Jianyuan; Shih, Alan; Zhong, Sue; Gu, Wei; Paolo Pandolfi, Pier. The function of PML in p53-dependent apoptosis. Nature Cell Biology. 2000-10, 2 (10) [2022-06-16]. ISSN 1465-7392. PMID 11025664. doi:10.1038/35036365. （原始內容存檔於2022-06-16） （英語）.
24. Alcalay, Myriam; Tomassoni, Lucia; Colombo, Emanuela; Stoldt, Stephan; Grignani, Francesco; Fagioli, Marta; Szekely, Laszlo; Helin, Kristian; Pelicci, Pier Giuseppe. The Promyelocytic Leukemia Gene Product (PML) Forms Stable Complexes with the Retinoblastoma Protein. Molecular and Cellular Biology. 1998-02, 18 (2) [2022-06-16]. ISSN 0270-7306. PMC 108821 . PMID 9448006. doi:10.1128/MCB.18.2.1084. （原始內容存檔於2022-06-16） （英語）.
25. Kawasaki, Akira; Matsumura, Itaru; Kataoka, Yoshihisa; Takigawa, Eri; Nakajima, Koichi; Kanakura, Yuzuru. Opposing effects of PML and PML/RARα on STAT3 activity. Blood. 2003-05-01, 101 (9) [2022-06-16]. ISSN 1528-0020. PMID 12506013. doi:10.1182/blood-2002-08-2474. （原始內容存檔於2022-06-16） （英語）.
26. Lin, Ding-Yen; Shih, Hsiu-Ming. Essential role of the 58-kDa microspherule protein in the modulation of Daxx-dependent transcriptional repression as revealed by nucleolar sequestration. The Journal of Biological Chemistry. 2002-07-12, 277 (28) [2022-06-16]. ISSN 0021-9258. PMID 11948183. doi:10.1074/jbc.M200633200. （原始內容存檔於2022-06-20）.
27. Kamitani, T.; Nguyen, H. P.; Kito, K.; Fukuda-Kamitani, T.; Yeh, E. T. Covalent modification of PML by the sentrin family of ubiquitin-like proteins. The Journal of Biological Chemistry. 1998-02-06, 273 (6) [2022-06-16]. ISSN 0021-9258. PMID 9452416. doi:10.1074/jbc.273.6.3117. （原始內容存檔於2022-06-20）.
28. Vallian, Sadeq; Chin, Khew-Voon; Chang, Kun-Sang. The Promyelocytic Leukemia Protein Interacts with Sp1 and Inhibits Its Transactivation of the Epidermal Growth Factor Receptor Promoter. Molecular and Cellular Biology. 1998-12, 18 (12) [2022-06-16]. ISSN 0270-7306. PMC 109296 . PMID 9819401. doi:10.1128/MCB.18.12.7147. （原始內容存檔於2022-06-16） （英語）.
29. Xu, Zhi-Xiang; Timanova-Atanasova, Anna; Zhao, Rui-Xun; Chang, Kun-Sang. PML Colocalizes with and Stabilizes the DNA Damage Response Protein TopBP1. Molecular and Cellular Biology. 2003-06-15, 23 (12). ISSN 0270-7306. PMC 156140 . PMID 12773567. doi:10.1128/MCB.23.12.4247-4256.2003 （英語）.
30. Takahashi, Hidehisa; Hatakeyama, Shigetsugu; Saitoh, Hisato; Nakayama, Keiichi I. Noncovalent SUMO-1 binding activity of thymine DNA glycosylase (TDG) is required for its SUMO-1 modification and colocalization with the promyelocytic leukemia protein. The Journal of Biological Chemistry. 2005-02-18, 280 (7) [2022-06-16]. ISSN 0021-9258. PMID 15569683. doi:10.1074/jbc.M408130200. （原始內容存檔於2022-06-16）.
31. Koken, M. H. M.; Reid, A.; Quignon, F.; Chelbi-Alix, M. K.; Davies, J. M.; Kabarowski, J. H. S.; Zhu, J.; Dong, S.; Chen, S.-J.; Chen, Z.; Tan, C. C. Leukemia-associated retinoic acid receptor α fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies. Proceedings of the National Academy of Sciences. 1997-09-16, 94 (19) [2022-06-16]. ISSN 0027-8424. PMC 23349 . PMID 9294197. doi:10.1073/pnas.94.19.10255. （原始內容存檔於2022-06-16） （英語）.

延伸閱讀

• Zhong, Sue; Salomoni, Paolo; Pandolfi, Pier Paolo. The transcriptional role of PML and the nuclear body. Nature Cell Biology. 2000-05, 2 (5) [2022-06-16]. ISSN 1465-7392. PMID 10806494. doi:10.1038/35010583. （原始內容存檔於2022-03-10） （英語）.
• Jensen, Kirsten; Shiels, Carol; Freemont, Paul S. PML protein isoforms and the RBCC/TRIM motif. Oncogene. 2001-10-29, 20 (49) [2022-06-16]. ISSN 0950-9232. PMID 11704850. doi:10.1038/sj.onc.1204765. （原始內容存檔於2022-05-25） （英語）.
• Pearson, Mark; Pelicci, Pier Giuseppe. PML interaction with p53 and its role in apoptosis and replicative senescence. Oncogene. 2001-10-29, 20 (49) [2022-06-16]. ISSN 0950-9232. PMID 11704853. doi:10.1038/sj.onc.1204856. （原始內容存檔於2022-06-16） （英語）.>
• Salomoni, Paolo; Pandolfi, Pier Paolo. The role of PML in tumor suppression. Cell. 2002-01-25, 108 (2) [2022-06-16]. ISSN 0092-8674. PMID 11832207. doi:10.1016/s0092-8674(02)00626-8. （原始內容存檔於2022-03-02）.
• Combes, Robert; Balls, Michael; Bansil, Lee; Barratt, Martin; Bell, David; Botham, Phil; Broadhead, Caren; Clothier, Richard; George, Elizabeth; Fentem, Julia; Jackson, Michael. An Assessment of Progress in the Use of Alternatives in Toxicity Testing since the Publication of the Report of the Second FRAME Toxicity Committee (1991). Alternatives to Laboratory Animals. 2002-07, 30 (4) [2022-06-16]. ISSN 0261-1929. PMID 12234245. doi:10.1177/026119290203000403. （原始內容存檔於2021-08-10） （英語）.
• Bernardi, Rosa; Pandolfi, Pier Paolo. Role of PML and the PML-nuclear body in the control of programmed cell death. Oncogene. 2003-12-08, 22 (56) [2022-06-16]. ISSN 0950-9232. PMID 14663483. doi:10.1038/sj.onc.1207106. （原始內容存檔於2022-06-16） （英語）.
• Beez, Sabine; Demmer, Philipp; Puccetti, Elena. Tse, William , 編. Targeting the Acute Promyelocytic Leukemia-Associated Fusion Proteins PML/RARα and PLZF/RARα with Interfering Peptides. PLoS ONE. 2012-11-09, 7 (11). ISSN 1932-6203. PMC 3494703 . PMID 23152790. doi:10.1371/journal.pone.0048636 （英語）.

外部連結

• 醫學主題詞表（MeSH）：PML+protein,+human