周期蛋白A1

Cyclin A1
周期素A1
Cyclin A1; 周期素A1
標識
代號	CCNA1
擴展標識	遺傳學：604036 鼠基因：108042 同源基因：31203 ChEMBL: 3609 GeneCards: CCNA1 Gene
基因本體論描述
分子功能	· protein binding; · protein kinase binding;
細胞成分	· nucleoplasm; · cytosol; · microtubule cytoskeleton;
生物過程	· regulation of cyclin-dependent protein serine/threonine kinase activity; · G1/S transition of mitotic cell cycle; · regulation of transcription involved in G1/S phase of mitotic cell cycle; · G2/M transition of mitotic cell cycle; · mitotic cell cycle; · mitosis; · male meiosis I; · spermatogenesis; · cell division;
	Sources: Amigo / QuickGO
RNA表達模式
	更多表達數據
直系同源體
物種	人類
Entrez	8900
Ensembl	ENSG00000133101
UniProt	P78396
mRNA序列	NM_001111045
蛋白序列	NP_001104515
基因位置	Chr 13:; 37.01 – 37.02 Mb
PubMed查詢	[1]
	閱; 論; 編;

周期蛋白A1（英語：Cyclin-A1，或譯為周期素A1）是一個由人類基因 CCNA1 編碼的蛋白質^[1]。

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該基因編碼的蛋白質屬於高度保守的周期蛋白家族，該家族成員的顯著特徵是貫穿細胞周期，其蛋白質豐度周期性地急劇改變。周期蛋白作為CDK（周期蛋白依賴性激酶）的調節因子。不同的周期蛋白表現出各自獨特的表達及降解特性，這有助於每個有絲分裂事件在時間上的協調性。周期蛋白A1表達於睾丸、大腦以及一些嚴重的白血病細胞系中，現任為其主要功能是控制減數分裂。該周期蛋白與Cdk1和Cdk2兩種激酶相結合，但這兩種激酶活性完全不相同，前者激酶活性表現於G2期，而後者激酶活性表現於S期，因此在細胞周期中調控了不同的功能。現發現這種周期蛋白可結合到重要的細胞周期調節物上，後者如：Rb家族蛋白、轉錄因子E2F1以及CDK抑制蛋白中的Kip/Cip家族^[2]。

相互作用

周期蛋白A1能與E2F1^[3]、CDC20^[4]、視網膜母細胞瘤蛋白^[3]、周期蛋白依賴性激酶2（英語：Cyclin-dependent kinase 2）^[1]^[5]^[6]^[7]、GPS2（英語：GPS2 (gene)）^[8] MYBL2^[6]和GNB2L1^[8]發生相互作用。

參考文獻

[1]
Yang R, Morosetti R, Koeffler HP. Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines. Cancer Res. March 1997, 57 (5): 913–20. PMID 9041194.
[2]
Entrez Gene: CCNA1 cyclin A1.
[3]
Yang, R; Müller C, Huynh V, Fung Y K, Yee A S, Koeffler H P. Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins. Mol. Cell. Biol. (UNITED STATES). March 1999, 19 (3): 2400–7. ISSN 0270-7306. PMC 84032 . PMID 10022926.
[4]
Ohtoshi, A; Maeda T, Higashi H, Ashizawa S, Hatakeyama M. Human p55(CDC)/Cdc20 associates with cyclin A and is phosphorylated by the cyclin A-Cdk2 complex. Biochem. Biophys. Res. Commun. (UNITED STATES). February 2000, 268 (2): 530–4. ISSN 0006-291X. PMID 10679238. doi:10.1006/bbrc.2000.2167.
[5]
Sweeney, C; Murphy M, Kubelka M, Ravnik S E, Hawkins C F, Wolgemuth D J, Carrington M. A distinct cyclin A is expressed in germ cells in the mouse. Development (ENGLAND). January 1996, 122 (1): 53–64. ISSN 0950-1991. PMID 8565853.
[6]
Müller-Tidow, C; Wang W, Idos G E, Diederichs S, Yang R, Readhead C, Berdel W E, Serve H, Saville M, Watson R, Koeffler H P. Cyclin A1 directly interacts with B-myb and cyclin A1/cdk2 phosphorylate B-myb at functionally important serine and threonine residues: tissue-specific regulation of B-myb function. Blood (United States). April 2001, 97 (7): 2091–7. ISSN 0006-4971. PMID 11264176. doi:10.1182/blood.V97.7.2091.
[7]
Brown, N R; Noble M E, Endicott J A, Johnson L N. The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases. Nat. Cell Biol. (England). November 1999, 1 (7): 438–43. ISSN 1465-7392. PMID 10559988. doi:10.1038/15674.
[8]
Diederichs, Sven; Bäumer Nicole, Ji Ping, Metzelder Stephan K, Idos Gregory E, Cauvet Thomas, Wang Wenbing, Möller Maria, Pierschalski Sarah, Gromoll Jörg, Schrader Mark G, Koeffler H Phillip, Berdel Wolfgang E, Serve Hubert, Müller-Tidow Carsten. Identification of interaction partners and substrates of the cyclin A1-CDK2 complex. J. Biol. Chem. (United States). August 2004, 279 (32): 33727–41. ISSN 0021-9258. PMID 15159402. doi:10.1074/jbc.M401708200.

延伸閱讀

Hall M, Bates S, Peters G. Evidence for different modes of action of cyclin-dependent kinase inhibitors: p15 and p16 bind to kinases, p21 and p27 bind to cyclins.. Oncogene. 1995, 11 (8): 1581–8. PMID 7478582.
Xu M, Sheppard KA, Peng CY; et al. Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation.. Mol. Cell. Biol. 1994, 14 (12): 8420–31. PMC 359381 . PMID 7969176.
Maruyama K, Sugano S. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.. Gene. 1994, 138 (1-2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8.
O'Connor PM, Ferris DK, Pagano M; et al. G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently.. J. Biol. Chem. 1993, 268 (11): 8298–308. PMID 8463339.
Sweeney C, Murphy M, Kubelka M; et al. A distinct cyclin A is expressed in germ cells in the mouse.. Development. 1996, 122 (1): 53–64. PMID 8565853.
Wang H, Shao N, Ding QM; et al. BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases.. Oncogene. 1997, 15 (2): 143–57. PMID 9244350. doi:10.1038/sj.onc.1201252.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.. Gene. 1997, 200 (1-2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3.
Liu D, Matzuk MM, Sung WK; et al. Cyclin A1 is required for meiosis in the male mouse.. Nat. Genet. 1998, 20 (4): 377–80. PMID 9843212. doi:10.1038/3855.
Yang R, Müller C, Huynh V; et al. Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins.. Mol. Cell. Biol. 1999, 19 (3): 2400–7. PMC 84032 . PMID 10022926.
Ravnik SE, Wolgemuth DJ. Regulation of meiosis during mammalian spermatogenesis: the A-type cyclins and their associated cyclin-dependent kinases are differentially expressed in the germ-cell lineage.. Dev. Biol. 1999, 207 (2): 408–18. PMID 10068472. doi:10.1006/dbio.1998.9156.
Yang R, Nakamaki T, Lübbert M; et al. Cyclin A1 expression in leukemia and normal hematopoietic cells.. Blood. 1999, 93 (6): 2067–74. PMID 10068680.
Müller C, Yang R, Beck-von-Peccoz L; et al. Cloning of the cyclin A1 genomic structure and characterization of the promoter region. GC boxes are essential for cell cycle-regulated transcription of the cyclin A1 gene.. J. Biol. Chem. 1999, 274 (16): 11220–8. PMID 10196209. doi:10.1074/jbc.274.16.11220.
Ruffner H, Jiang W, Craig AG; et al. BRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation site.. Mol. Cell. Biol. 1999, 19 (7): 4843–54. PMC 84283 . PMID 10373534.
Brown NR, Noble ME, Endicott JA, Johnson LN. The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases.. Nat. Cell Biol. 2001, 1 (7): 438–43. PMID 10559988. doi:10.1038/15674.
Liu D, Liao C, Wolgemuth DJ. A role for cyclin A1 in the activation of MPF and G2-M transition during meiosis of male germ cells in mice.. Dev. Biol. 2000, 224 (2): 388–400. PMID 10926775. doi:10.1006/dbio.2000.9776.
Hartley JL, Temple GF, Brasch MA. DNA cloning using in vitro site-specific recombination.. Genome Res. 2001, 10 (11): 1788–95. PMC 310948 . PMID 11076863. doi:10.1101/gr.143000.
Müller-Tidow C, Bornemann C, Diederichs S; et al. Analyses of the genomic methylation status of the human cyclin A1 promoter by a novel real-time PCR-based methodology.. FEBS Lett. 2001, 490 (1-2): 75–8. PMID 11172814. doi:10.1016/S0014-5793(01)02128-7.
Simpson JC, Wellenreuther R, Poustka A; et al. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.. EMBO Rep. 2001, 1 (3): 287–92. PMC 1083732 . PMID 11256614. doi:10.1093/embo-reports/kvd058.
Müller-Tidow C, Wang W, Idos GE; et al. Cyclin A1 directly interacts with B-myb and cyclin A1/cdk2 phosphorylate B-myb at functionally important serine and threonine residues: tissue-specific regulation of B-myb function.. Blood. 2001, 97 (7): 2091–7. PMID 11264176. doi:10.1182/blood.V97.7.2091.

[pmid9041194-1] [1]
Yang R, Morosetti R, Koeffler HP. Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines. Cancer Res. March 1997, 57 (5): 913–20. PMID 9041194.

[entrez-2] [2]
Entrez Gene: CCNA1 cyclin A1.

[pmid10022926-3] [3]
Yang, R; Müller C, Huynh V, Fung Y K, Yee A S, Koeffler H P. Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins. Mol. Cell. Biol. (UNITED STATES). March 1999, 19 (3): 2400–7. ISSN 0270-7306. PMC 84032 . PMID 10022926.

[pmid10679238-4] [4]
Ohtoshi, A; Maeda T, Higashi H, Ashizawa S, Hatakeyama M. Human p55(CDC)/Cdc20 associates with cyclin A and is phosphorylated by the cyclin A-Cdk2 complex. Biochem. Biophys. Res. Commun. (UNITED STATES). February 2000, 268 (2): 530–4. ISSN 0006-291X. PMID 10679238. doi:10.1006/bbrc.2000.2167.

[pmid8565853-5] [5]
Sweeney, C; Murphy M, Kubelka M, Ravnik S E, Hawkins C F, Wolgemuth D J, Carrington M. A distinct cyclin A is expressed in germ cells in the mouse. Development (ENGLAND). January 1996, 122 (1): 53–64. ISSN 0950-1991. PMID 8565853.

[pmid11264176-6] [6]
Müller-Tidow, C; Wang W, Idos G E, Diederichs S, Yang R, Readhead C, Berdel W E, Serve H, Saville M, Watson R, Koeffler H P. Cyclin A1 directly interacts with B-myb and cyclin A1/cdk2 phosphorylate B-myb at functionally important serine and threonine residues: tissue-specific regulation of B-myb function. Blood (United States). April 2001, 97 (7): 2091–7. ISSN 0006-4971. PMID 11264176. doi:10.1182/blood.V97.7.2091.

[pmid10559988-7] [7]
Brown, N R; Noble M E, Endicott J A, Johnson L N. The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases. Nat. Cell Biol. (England). November 1999, 1 (7): 438–43. ISSN 1465-7392. PMID 10559988. doi:10.1038/15674.

[pmid15159402-8] [8]
Diederichs, Sven; Bäumer Nicole, Ji Ping, Metzelder Stephan K, Idos Gregory E, Cauvet Thomas, Wang Wenbing, Möller Maria, Pierschalski Sarah, Gromoll Jörg, Schrader Mark G, Koeffler H Phillip, Berdel Wolfgang E, Serve Hubert, Müller-Tidow Carsten. Identification of interaction partners and substrates of the cyclin A1-CDK2 complex. J. Biol. Chem. (United States). August 2004, 279 (32): 33727–41. ISSN 0021-9258. PMID 15159402. doi:10.1074/jbc.M401708200.

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