北周攻打南陳，奪取秦州秦郡，改置為方州六合郡，治所在尉氏縣（今江蘇省南京市六合區），以六合山得名。下轄尉氏縣、堂邑縣、方山縣。隋文帝開皇三年（583年）廢六合郡，下轄諸縣歸屬方州。
參考文獻
- 《中國行政區劃通史·十六國北朝卷》
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