M33基因是果蝇属（Drosophila）多梳家族蛋白在哺乳动物基因组中的直系同源物[1]，在人类基因组中为CBX2基因，在小鼠基因组中为Cbx2，表达的蛋白全长519aa，带有一个克罗莫结构域和核定位序列[2]。
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