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口服免疫耐受性降低（請參考免疫耐受中英文部分#Oral tolerance and hypersensitivity） 腸道菌叢失衡 腸通透性（英语：Intestinal permeability）被強化 免疫性反應情況增加 自體免疫發生 化學物質可直接存在環境中，或以藥物形式存在，譬如：聯氨、染髮劑、三氯乙烯、檸檬黃、危險廢棄物（英语：Hazardous

(帮助) Parlesak A, Schäfer C, Schütz T, Bode JC, Bode C. Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol