葡萄糖转运蛋白4型(英语:Glucose transporter type 4,简称GLUT4),也称为溶质载体家族2(solute carrier family 2)和促进葡萄糖转运蛋白成员4(facilitated glucose transporter member 4),是一种在人类中由SLC2A4基因编码的蛋白质。GLUT4是调节胰岛素的葡萄糖转运蛋白,主要存在于脂肪组织和横纹肌(骨骼肌和心脏)中。大卫·詹姆斯于1988年提供了这种独特的葡萄糖转运蛋白的第一个证据。[1]编码GLUT4的基因于1989年被克隆[2][3]和定位。[4]
Buchberger A, Howard MJ, Proctor M, Bycroft M. The UBX domain: a widespread ubiquitin-like module. Journal of Molecular Biology. March 2001, 307 (1): 17–24. PMID 11243799. doi:10.1006/jmbi.2000.4462.
Laybutt DR, Thompson AL, Cooney GJ, Kraegen EW. Selective chronic regulation of GLUT1 and GLUT4 content by insulin, glucose, and lipid in rat cardiac muscle in vivo. The American Journal of Physiology. September 1997, 273 (3 Pt 2): H1309–16. PMID 9321820. doi:10.1152/ajpheart.1997.273.3.H1309(英语).
Sylow L, Kleinert M, Pehmøller C, Prats C, Chiu TT, Klip A, Richter EA, Jensen TE. Akt and Rac1 signaling are jointly required for insulin-stimulated glucose uptake in skeletal muscle and downregulated in insulin resistance. Cellular Signalling. February 2014, 26 (2): 323–31. PMID 24216610. doi:10.1016/j.cellsig.2013.11.007.
Mu J, Brozinick JT, Valladares O, Bucan M, Birnbaum MJ. A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscle. Molecular Cell. May 2001, 7 (5): 1085–94. PMID 11389854. doi:10.1016/s1097-2765(01)00251-9.
Lalioti VS, Vergarajauregui S, Pulido D, Sandoval IV. The insulin-sensitive glucose transporter, GLUT4, interacts physically with Daxx. Two proteins with capacity to bind Ubc9 and conjugated to SUMO1. The Journal of Biological Chemistry. May 2002, 277 (22): 19783–91. PMID 11842083. doi:10.1074/jbc.M110294200.
Huang CC, Lee CC, Hsu KS. The role of insulin receptor signaling in synaptic plasticity and cognitive function. Chang Gung Medical Journal. 2010, 33 (2): 115–25. PMID 20438663.