De novo mutation

Lin, Guan Ning; Malhotra, Dheeraj. Frequency and Complexity of De Novo Structural Mutation in Autism. The American Journal of Human Genetics. 24 March 2016

Hee-Suk; Qiu, Xing; Sambuughin, Nyamkhishig; Dirksen, Robert T. Identical de novo Mutation in the Type 1 Ryanodine Receptor Gene Associated with Fatal, Stress-induced

monoclonal antibodies in biotechnology. HAT medium（英语：HAT medium） inhibits de novo synthesis of nucleic acids, killing myeloma cells that cannot switch over

HF, et al. CEBPA methylation as a prognostic biomarker in patients with de novo acute myeloid leukemia. Leukemia. 2011, 25 (1): 32–40. PMID 20927134. doi:10

gene formation）、基因截短（gene truncation）、以及招收非編碼序列等直接形成（de novo origination）機制。 基因複製發生時，一段基因序列產生另一份複製，而有了冗餘重複，重複的基因可以突變出不同功能而不影響原本的功能，