脂联素受体1

Adiponectin receptor 1
脂联素受体1
Adiponectin receptor 1; 脂联素受体1
标识
代号	ADIPOR1; ACDCR1; CGI45; PAQR1; TESBP1A
扩展标识	遗传学：607945 鼠基因：1919924 同源基因：69199 IUPHAR: GeneCards: ADIPOR1 Gene
基因本体论描述
分子功能	· receptor activity; · protein kinase binding; · hormone binding; · identical protein binding; · protein heterodimerization activity;
细胞成分	· plasma membrane; · membrane; · integral component of membrane;
生物过程	· hormone-mediated signaling pathway; · fatty acid oxidation; · negative regulation of cell growth; · leptin-mediated signaling pathway; · adiponectin-activated signaling pathway; · positive regulation of JAK-STAT cascade; · positive regulation of insulin receptor signaling pathway;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体
物种	人类
Entrez	51094
Ensembl	ENSG00000159346
UniProt	Q96A54
mRNA序列	NM_001290553
蛋白序列	NP_001277482
基因位置	Chr 1:; 202.91 – 202.93 Mb
PubMed查询	[1]
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脂联素受体1（英语：Adiponectin receptor 1，缩写ADIPOR1）是一种由人类基因 ADIPOR1 编码的蛋白质^[1]。

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结构

ADIPOR1和G蛋白偶联受体（GPCRs）类似，都拥有7个跨膜结构域（英语：transmembrane domain）。但是ADIPOR1的七跨膜的位置与GPCRs相反，N-端在细胞内，C-端在细胞外，也不能与G蛋白相互作用^[1]。

功能

脂联素的受体，ADIPOR1和ADIPOR2，能应答球状或全长的脂联素信号，促使AMPK（英语：AMP-activated protein kinase）和PPAR-α（英语：Peroxisome proliferator-activated receptor alpha）配体活性增加，以及脂肪酸的氧化和葡萄糖摄取^[1]^[2]。

参考文献

[1]
Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature. June 2003, 423 (6941): 762–9. PMID 12802337. doi:10.1038/nature01705.
[2]
Entrez Gene: ADIPOR1 adiponectin receptor 1.

延伸阅读

Crimmins NA, Martin LJ. Polymorphisms in adiponectin receptor genes ADIPOR1 and ADIPOR2 and insulin resistance.. Obesity reviews : an official journal of the International Association for the Study of Obesity. 2007, 8 (5): 419–23. PMID 17716299. doi:10.1111/j.1467-789X.2007.00348.x.
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Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.. Gene. 1997, 200 (1-2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3.
Lai CH, Chou CY, Ch'ang LY; et al. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.. Genome Res. 2000, 10 (5): 703–13. PMC 310876 . PMID 10810093. doi:10.1101/gr.10.5.703.
Strausberg RL, Feingold EA, Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Yamauchi T, Kamon J, Ito Y; et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects.. Nature. 2003, 423 (6941): 762–9. PMID 12802337. doi:10.1038/nature01705.
Kharroubi I, Rasschaert J, Eizirik DL, Cnop M. Expression of adiponectin receptors in pancreatic beta cells.. Biochem. Biophys. Res. Commun. 2004, 312 (4): 1118–22. PMID 14651988. doi:10.1016/j.bbrc.2003.11.042.
Ota T, Suzuki Y, Nishikawa T; et al. Complete sequencing and characterization of 21,243 full-length human cDNAs.. Nat. Genet. 2004, 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Civitarese AE, Jenkinson CP, Richardson D; et al. Adiponectin receptors gene expression and insulin sensitivity in non-diabetic Mexican Americans with or without a family history of Type 2 diabetes.. Diabetologia. 2005, 47 (5): 816–20. PMID 15105989. doi:10.1007/s00125-004-1359-x.
Wang H, Zhang H, Jia Y; et al. Adiponectin receptor 1 gene (ADIPOR1) as a candidate for type 2 diabetes and insulin resistance.. Diabetes. 2004, 53 (8): 2132–6. PMID 15277397. doi:10.2337/diabetes.53.8.2132.
Staiger H, Kaltenbach S, Staiger K; et al. Expression of adiponectin receptor mRNA in human skeletal muscle cells is related to in vivo parameters of glucose and lipid metabolism.. Diabetes. 2004, 53 (9): 2195–201. PMID 15331527. doi:10.2337/diabetes.53.9.2195.
Berner HS, Lyngstadaas SP, Spahr A; et al. Adiponectin and its receptors are expressed in bone-forming cells.. Bone. 2005, 35 (4): 842–9. PMID 15454091. doi:10.1016/j.bone.2004.06.008.
Gerhard DS, Wagner L, Feingold EA; et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Punyadeera C, Zorenc AH, Koopman R; et al. The effects of exercise and adipose tissue lipolysis on plasma adiponectin concentration and adiponectin receptor expression in human skeletal muscle.. Eur. J. Endocrinol. 2005, 152 (3): 427–36. PMID 15757860. doi:10.1530/eje.1.01872.
Hara K, Horikoshi M, Kitazato H; et al. Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes.. Diabetologia. 2005, 48 (7): 1307–14. PMID 15918014. doi:10.1007/s00125-005-1806-3.
Damcott CM, Ott SH, Pollin TI; et al. Genetic variation in adiponectin receptor 1 and adiponectin receptor 2 is associated with type 2 diabetes in the Old Order Amish.. Diabetes. 2005, 54 (7): 2245–50. PMID 15983228. doi:10.2337/diabetes.54.7.2245.
Neumeier M, Weigert J, Schäffler A; et al. Regulation of adiponectin receptor 1 in human hepatocytes by agonists of nuclear receptors.. Biochem. Biophys. Res. Commun. 2006, 334 (3): 924–9. PMID 16023994. doi:10.1016/j.bbrc.2005.06.187.
Zhang J, Holt H, Wang C; et al. Expression of AdipoR1 in vivo in skeletal muscle is independently associated with measures of truncal obesity in middle-aged caucasian men.. Diabetes Care. 2005, 28 (8): 2058–60. PMID 16043761. doi:10.2337/diacare.28.8.2058.
Tang YT, Hu T, Arterburn M; et al. PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif.. J. Mol. Evol. 2005, 61 (3): 372–80. PMID 16044242. doi:10.1007/s00239-004-0375-2.
Jonsson JR, Moschen AR, Hickman IJ; et al. Adiponectin and its receptors in patients with chronic hepatitis C.. J. Hepatol. 2006, 43 (6): 929–36. PMID 16139921. doi:10.1016/j.jhep.2005.05.030.

[pmid12802337-1] [1]
Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature. June 2003, 423 (6941): 762–9. PMID 12802337. doi:10.1038/nature01705.

[entrez-2] [2]
Entrez Gene: ADIPOR1 adiponectin receptor 1.

[1]

[2]